The essential pathophysiological roles of hyaluronic acid (HA) strongly depend on HA
binding and HA size. Here we deployed the atomic vision of molecular dynamics (MD) …

The mechanism of hyaluronan biosynthesis in vertebrates had been proposed to occur at
the reducing end of growing chains. This mechanism was questioned because a …

Hyaluronan is an extremely important polysaccharide from both the biological and
commercial points of view. This review summarizes the present state of the art concerning …

Streptococcus equisimilis hyaluronan (HA) synthase (SeHAS) contains four cysteines
(C226, C262, C281 and C367) that are conserved in the mammalian HAS family. Previous …

Hyaluronic acid (HA) based biomaterials have several biomedical applications. HA
biosynthesis is catalysed by hyaluronan synthase (HAS). The unavailability of 3-D structure …

Hyaluronic acid (HA) is a naturally formed acidic mucopolysaccharide, with excellent
moisturising properties and used widely in the medicine, cosmetics, and food industries. The …

The Class I hyaluronan synthase (HAS) is a unique glycosyltransferase synthesizing
hyaluronan (HA), a polysaccharide composed of GlcUA and GlcNAc, by using one catalytic …

Hyaluronic acid (HA) is a glycosaminoglycan crucial for the homeostasis of tissues, and its
role on cell signalling and regulation of tissue injury and repair largely depends on HA …

This paper reports the synthesis of hyaluronan (HA) and its derivatives via the hyaluronidase-
catalyzed polymerization of 2-substituted oxazoline derivative monomers designed as …

Hyaluronic acid (HA) is a major glycosaminoglycan, a family of structurally complex, linear,
anionic hetero-co-polysaccharides. HA is important in various anatomical structures …