Association of polygenic variants with type 2 diabetes risk and their interaction with lifestyles in Asians

HJ Hur, HJ Yang, MJ Kim, KH Lee, MS Kim, S Park - Nutrients, 2022 - mdpi.com
Over the last several decades, there has been a considerable growth in type 2 diabetes
(T2DM) in Asians. A pathophysiological mechanism in Asian T2DM is closely linked to low …

Gene–diet interactions on metabolic disease-related outcomes in Southeast Asian populations: a systematic review

P Sekar, EF Ventura, ACTA Dhanapal, ESG Cheah… - Nutrients, 2023 - mdpi.com
Diabetes and obesity are chronic diseases that are a burden to low-and middle-income
countries. We conducted this systematic review to understand gene–diet interactions …

[HTML][HTML] Genetic insights into cardiometabolic risk factors

JB Whitfield - The Clinical Biochemist Reviews, 2014 - ncbi.nlm.nih.gov
Many biochemical traits are recognised as risk factors, which contribute to or predict the
development of disease. Only a few are in widespread use, usually to assist with treatment …

Genetic risk variants for metabolic traits in Arab populations

P Hebbar, N Elkum, F Alkayal, SE John, TA Thanaraj… - Scientific reports, 2017 - nature.com
Despite a high prevalence of metabolic trait related diseases in Arabian Peninsula, there is
a lack of convincingly identified genetic determinants for metabolic traits in this population …

Association of structural variation with cardiometabolic traits in Finns

L Chen, HJ Abel, I Das, DE Larson, L Ganel… - The American Journal of …, 2021 - cell.com
The contribution of genome structural variation (SV) to quantitative traits associated with
cardiometabolic diseases remains largely unknown. Here, we present the results of a study …

Nutritional genomics of cardiovascular disease

VS Voruganti - Current genetic medicine reports, 2018 - Springer
Abstract Purpose of Review Cardiovascular disease (CVD) is the leading cause of death in
the USA and globally. There is significant evidence implicating genetic and dietary factors in …

Multiancestry study of gene–lifestyle interactions for cardiovascular traits in 610 475 individuals from 124 cohorts: design and rationale

DC Rao, YJ Sung, TW Winkler… - Circulation …, 2017 - Am Heart Assoc
Background—Several consortia have pursued genome-wide association studies for
identifying novel genetic loci for blood pressure, lipids, hypertension, etc. They …

Gene–diet interactions in cardiovascular disease

ME Dimitriou, GVZ Dedoussis - Current Nutrition Reports, 2012 - Springer
Cardiovascular disease (CVD), the leading cause of mortality worldwide, results from a
complex interplay between genetic and environmental factors. Genetic studies identified …

Gene-diet interaction effects on BMI levels in the Singapore Chinese population

X Chang, R Dorajoo, Y Sun, Y Han, L Wang, CC Khor… - Nutrition journal, 2018 - Springer
Background Recent genome-wide association studies (GWAS) have identified 97 body-
mass index (BMI) associated loci. We aimed to evaluate if dietary intake modifies BMI …

Pleiotropy of cardiometabolic syndrome with obesity-related anthropometric traits determined using empirically derived kinships from the Busselton Health Study

G Cadby, PE Melton, NS McCarthy, M Almeida… - Human genetics, 2018 - Springer
Over two billion adults are overweight or obese and therefore at an increased risk of
cardiometabolic syndrome (CMS). Obesity-related anthropometric traits genetically …