Association of genome-wide polygenic risk score for body mass index with cardiometabolic health from childhood through midlife

M Shi, W Chen, X Sun, LA Bazzano, J He… - Circulation: Genomic …, 2022 - Am Heart Assoc
Background: Genetic information may help to identify individuals in childhood who are at
increased risk for cardiometabolic disease. Methods: We included 1201 BHS (Bogalusa …

Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistanis and Bangladeshis

QQ Huang, N Sallah, D Dunca, B Trivedi, KA Hunt… - medRxiv, 2021 - medrxiv.org
Abstract Background Individuals with South Asian ancestry have higher risk of heart disease
than other groups in Western countries; however, most genetic research has focused on …

The Mediterranean diet reduces the genetic risk of chromosome 9p21 for myocardial infarction in an Asian population community cohort

HB Leu, CM Chung, JW Chen, WH Pan - Scientific reports, 2019 - nature.com
The interaction of genetic susceptibility and dietary habits in cardiovascular disease (CVD)
remains undetermined. The purpose of this study was to investigate whether a …

Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an …

CM Povel, JMA Boer, NC Onland-Moret… - Cardiovascular …, 2012 - Springer
Background Mechanisms involved in metabolic syndrome (MetS) development include
insulin resistance, weight regulation, inflammation and lipid metabolism. Aim of this study is …

[HTML][HTML] Genetic identification for non-communicable disease: Findings from 20 years of the Tehran Lipid and Glucose Study

MS Daneshpour, M Hedayati… - … of endocrinology and …, 2018 - ncbi.nlm.nih.gov
Results This review summarizes associations of 6 binary phenotypes and 17 quantitative
traits with genetic markers in 26 genes. Of the 47 genetic markers, studied most were related …

Use of a gene score of multiple low-modest effect size variants can predict the risk of obesity better than the individual SNPs

Shabana, SU Shahid, S Hasnain - Lipids in Health and Disease, 2018 - Springer
Background Obesity is a complex disorder, the development of which is modulated by a
multitude of environmental, behavioral and genetic factors. The common forms of obesity are …

Multiple metabolic genetic risk scores and type 2 diabetes risk in three racial/ethnic groups

YC Klimentidis, NE Wineinger… - The Journal of …, 2014 - academic.oup.com
Context/Rationale: Meta-analyses of genome-wide association studies have identified many
single-nucleotide polymorphisms associated with various metabolic and cardiovascular …

Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study

S Ahmad, W Zhao, F Renström, A Rasheed… - BMC medical …, 2015 - Springer
Background Multiple genetic variants have been reliably associated with obesity-related
traits in Europeans, but little is known about their associations and interactions with lifestyle …

Cardio-metabolic disease genetic risk factors among Māori and Pacific Island people in Aotearoa New Zealand: current state of knowledge and future directions

TR Merriman, PL Wilcox - Annals of Human Biology, 2018 - Taylor & Francis
Context: Cardio-metabolic conditions in Aotearoa New Zealand (NZ) Māori and non-
indigenous Polynesian (Pacific) populations have been increasing in prevalence and …

Application of single-nucleotide polymorphism-related risk estimates in identification of increased genetic susceptibility to cardiovascular diseases: a literature review

S Fiatal, R Adany - Frontiers in public health, 2018 - frontiersin.org
Background Although largely preventable, cardiovascular diseases (CVDs) are the biggest
cause of death worldwide. Common complex cardiovascular disorders (eg, coronary heart …