Background & aims We aimed to assess the performance of European-derived polygenic
risk scores (PRSs) for common metabolic diseases such as coronary artery disease (CAD) …

Introduction: Personalized diets based on an individual's genome to optimize the success of
dietary intervention and reduce genetic cardiovascular disease (CVD) risk, is one of the …

BACKGROUND With modernization, cardiometabolic disease risk has increased in low and
middle-income countries. To better understand cardiometabolic disease etiology, we …

Background: Computing polygenic risk scores (PRS) to predict the degree of risk for obesity
may contribute to weight management programs strategically. Objectives: To investigate the …

Aims/hypothesis Little is known about the heritable basis of gene–environment interactions
in humans. We therefore screened multiple cardiometabolic traits to assess the probability …

Background: Previous studies reporting on the interaction between physical activity and
genetic susceptibility on obesity have been cross-sectional and have not considered the …

Background The clinical utility of personal genomic information in identifying individuals at
increased risks for dyslipidemia and cardiovascular diseases remains unclear. Methods We …

Genome-wide association studies have successfully identified thousands of loci for a range
of human complex traits and diseases. The proportion of phenotypic variance explained by …

Nutrigenomics represents a suitable approach to cardio-vascular medicine, potentially
enabling both, better prevention and treatment of cardiovascular diseases (CVD) through …

Background Coronary artery disease (CAD) remains the single most important cause of
mortality worldwide. Many candidate and GWAS genetic variants have been identified in the …