Background Germline mutations in the BRCA1 and BRCA2 genes predispose carriers to
breast and ovarian cancer, and there remains a need to identify the specific genomic …

Background Inherited mutations in the BRCA2 gene greatly increase the risk of developing
breast cancer. Consistent with an important role for BRCA2 in error-free DNA repair …

BRCA1 encodes a tumour suppressor protein that plays pivotal roles in homologous
recombination (HR) DNA repair, cell‐cycle checkpoints, and transcriptional regulation …

Introduction BRCA1 or BRCA2 germline mutations increase the risk of developing breast
cancer. Tumour cells from germline mutation carriers have frequently lost the wild-type …

BRCA1 or BRCA2 germline mutations cause∼ 30% of breast cancers within high-risk
families. This represents 5% of total breast cancer incidence. Although BRCA1 and BRCA2 …

Background A mutation found in the BRCA1 or BRCA2 gene of a breast tumor could be
either germline or somatically acquired. The prevalence of somatic BRCA1/2 mutations and …

BRCA1 and BRCA2 mutations confer increased risk for development of breast cancer, but a
number of additional, currently largely unknown, somatic genetic defects must also …

Simple Summary Germline and somatic BRCA1/2 mutations may define therapeutic targets
and refine cancer treatment options. However, routine BRCA diagnostic approaches cannot …

Germline pathogenic mutations in BRCA1 increase risk of developing breast cancer.
Screening for mutations in BRCA1 frequently identifies sequence variants of unknown …

Introduction BRCA1-mutated breast carcinomas may have distinct biological features,
suggesting the involvement of specific oncogenic pathways in tumor development. The …