Caspase-8 is a protease with both pro-death and pro-survival functions: it mediates
apoptosis induced by death receptors such as TNFR1, and suppresses necroptosis …

Caspase-8 is the initiator caspase of extrinsic apoptosis, and inhibits necroptosis mediated
by RIPK3 and MLKL. Accordingly, caspase-8 deficiency in mice causes embryonic lethality …

The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell death
mediated by RIPK3 and MLKL. Indeed, mice that lack caspase-8 die in a RIPK3-and MLKL …

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal
inflammatory response, RIPK1 is regulated post-translationally by well-characterized …

Regulated cell death has essential functions in development and in adult tissue
homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis that requires …

Caspases function in both apoptosis and inflammatory cytokine processing and thereby
have a role in resistance to sepsis. Here we describe a novel role for a caspase in …

Caspase-3 carries out the executioner phase of apoptosis, however under special
circumstances, cells can survive its activity. To document systematically where and when …

Caspases are essential components of the mammalian cell death machinery. Here we test
the hypothesis that Caspase 9 (Casp9) is a critical upstream activator of caspases through …

Apoptosis and necroptosis are complementary pathways controlled by common signalling
adaptors, kinases and proteases; among these, caspase-8 (Casp8) is critical for death …

Caspase-8 has two opposing biological functions—it promotes cell death by triggering the
extrinsic pathway of apoptosis, but also has a survival activity, as it is required for embryonic …