Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention

PR Angelova, N Esteras… - Medicinal Research …, 2021 - Wiley Online Library
The world's population aging progression renders age‐related neurodegenerative diseases
to be one of the biggest unsolved problems of modern society. Despite the progress in …

Lipid peroxidation in neurodegeneration

C Peña-Bautista, M Vento, M Baquero… - Clinica Chimica …, 2019 - Elsevier
Neurodegenerative diseases have great social and economic impact and cause millions of
deaths every year. The potential molecular mechanisms in these pathologies have been …

Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies

HA Elfawy, B Das - Life sciences, 2019 - Elsevier
Mitochondrial function is vital for normal cellular processes. Mitochondrial damage and
oxidative stress have been greatly implicated in the progression of aging, along with the …

Insights into the pathogenesis of neurodegenerative diseases: Focus on mitochondrial dysfunction and oxidative stress

A Jurcau - International journal of molecular sciences, 2021 - mdpi.com
As the population ages, the incidence of neurodegenerative diseases is increasing. Due to
intensive research, important steps in the elucidation of pathogenetic cascades have been …

Oxidative stress in neurodegenerative diseases: from a mitochondrial point of view

G Cenini, A Lloret, R Cascella - Oxidative medicine and …, 2019 - Wiley Online Library
Age is the main risk factor for a number of human diseases, including neurodegenerative
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …

Oxidative toxicity in neurodegenerative diseases: role of mitochondrial dysfunction and therapeutic strategies

K Facecchia, LA Fochesato, SD Ray… - Journal of …, 2011 - Wiley Online Library
Besides fluorine, oxygen is the most electronegative element with the highest reduction
potential in biological systems. Metabolic pathways in mammalian cells utilize oxygen as the …

Oxidative stress, mitochondrial damage and neurodegenerative diseases

C Guo, L Sun, X Chen, D Zhang - Neural regeneration research, 2013 - journals.lww.com
Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of
several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease …

Mitochondrial inhibition and oxidative stress: reciprocating players in neurodegeneration

GD Zeevalk, LP Bernard, C Song, M Gluck… - Antioxidants & redox …, 2005 - liebertpub.com
Although the etiology for many neurodegenerative diseases is unknown, the common
findings of mitochondrial defects and oxidative damage posit these events as contributing …

Targeting oxidative stress mechanisms to treat Alzheimer's and Parkinson's disease: a critical review

AT Aborode, M Pustake, WA Awuah… - Oxidative medicine …, 2022 - Wiley Online Library
Neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease
(PD) are becoming more frequent as the age increases. Contemporary therapies provide …

Mitochondrial dysfunction, oxidative stress and neurodegeneration

M Mancuso, F Coppede, L Migliore… - Journal of …, 2006 - content.iospress.com
Mitochondria play a critical role in several metabolic processes and apoptotic pathways,
regulating life cycle from the cradle to the grave. Despite the evidence of morphological …