The nuclear RNA exosome complex mediates the processing of structured RNAs and the
decay of aberrant non-coding RNAs, an important function particularly in human cells. Most …

The exosome is a key RNA machine that functions in the degradation of unwanted RNA s.
Here, we found that significant fractions of precursors and mature forms of mRNA s and long …

The human exosome is a 3′–5′ exoribonuclease complex that functions both in the
nucleus and in the cytoplasm to either degrade or process RNA. Little is known yet about …

Many long noncoding RNAs (lncRNAs) are unstable and rapidly degraded in the nucleus by
the nuclear exosome. An exosome adaptor complex called NEXT (nuclear exosome …

In eukaryotes, the exosome complex degrades RNA backbones and plays key roles in RNA
processing and surveillance. It was predicted that RNA substrates are threaded through a …

Nuclear processing and quality control of eukaryotic RNA is mediated by the RNA exosome,
which is regulated by accessory factors. However, the mechanism of exosome recruitment to …

The nuclear RNA exosome is an essential and versatile machinery that regulates maturation
and degradation of a huge plethora of RNA species. The past two decades have witnessed …

The RNA exosome complex functions in both the accurate processing and rapid
degradation of many classes of RNA. Functional and structural analyses indicate that RNA …

The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …

This chapter reviews the present state of knowledge on the activity of enzymes that function
with the RNA exosome in the nucleus. In this compartment, the exosome interacts physically …