The RNA exosome is a 3′ to 5′ ribonuclease that plays a fundamental role in maturation,
quality control, and turnover of nearly all types of RNA produced in eukaryotic cells. Here …

The yeast nuclear exosome contains multiple 3′→ 5′ exoribonucleases, raising the
question of why so many activities are present in the complex. All components are required …

The eukaryotic RNA exosome is an essential, multi-subunit complex that catalyzes RNA
turnover, maturation, and quality control processes. Its non-catalytic donut-shaped core …

The diversity of RNAs in the cell continues to amaze. In addition to the 'classic'species of
mRNA, tRNA, rRNA, snRNA and snoRNA, it is now clear that the majority of genomic …

Cell-based studies of human ribonucleases traditionally rely on methods that deplete
proteins slowly. We engineered cells in which the 3′→ 5′ exoribonucleases of the …

The RNA exosome complex processes and degrades a wide range of transcripts, including
ribosomal RNAs (rRNAs). We used cryo–electron microscopy to visualize the yeast nuclear …

RNA quality control relies on co-factors and adaptors to identify and prepare substrates for
degradation by ribonucleases such as the 3′ to 5′ ribonucleolytic RNA exosome. Here …

Turnover of nucleoplasmic transcripts by the mammalian multi-subunit RNA exosome is
mediated by two adaptors: the Nuclear EXosome Targeting (NEXT) complex and the Poly …

The RNA that is packaged into exosomes is termed as exosomal-shuttle RNA (esRNA);
however, the players, which take this subset of RNA (esRNA) into exosomes, remain largely …

The exosome is a complex involved in the maturation of rRNA and sn-snoRNA, in the
degradation of short-lived noncoding RNAs, and in the quality control of RNAs produced in …