Terminal balls detected at the 5′-end of nascent ribosomal transcripts act as pre-rRNA
processing complexes and are detected in all eukaryotes examined, resulting in illustrious …

The advent of high‐throughput sequencing technologies has revealed that pervasive
transcription generates RNAs from nearly all regions of eukaryotic genomes. Normally …

The eukaryotic exosome is a conserved RNA-degrading complex that functions in RNA
surveillance, turnover and processing. How the same machinery can either completely …

The exosome is a complex involved in the maturation of rRNA and sn-snoRNA, in the
degradation of short-lived noncoding RNAs, and in the quality control of RNAs produced in …

The exosome complex is a key component of the cellular RNA surveillance machinery and
is required for normal 3′ end processing of many stable RNAs. Exosome activity requires …

The RNA exosome is an essential ribonuclease complex involved in RNA processing and
decay. It consists of a 9-subunit catalytically inert ring composed of six RNase PH-like …

A genome-wide screen for synthetic lethal (SL) interactions with loss of the nuclear exosome
cofactors Rrp47/Lrp1 or Air1 identified 3′→ 5′ exonucleases, the THO complex required …

One of the most important protein complexes involved in maintaining correct RNA levels in
eukaryotic cells is the exosome, a complex consisting almost exclusively of …

Related exosome complexes of 3′→ 5′ exonucleases are present in the nucleus and the
cytoplasm. Purification of exosome complexes from whole-cell lysates identified a Mg 2+ …

A key question in the field of RNA regulation is how some exosome substrates, such as
spliceosomal snRNAs and telomerase RNA, evade degradation and are processed into …