Architecture of the yeast Rrp44–exosome complex suggests routes of RNA recruitment for 3′ end processing
HW Wang, J Wang, F Ding… - Proceedings of the …, 2007 - National Acad Sciences
The eukaryotic core exosome (CE) is a conserved nine-subunit protein complex important
for 3′ end trimming and degradation of RNA. In yeast, the Rrp44 protein constitutively …
for 3′ end trimming and degradation of RNA. In yeast, the Rrp44 protein constitutively …
Origins and activities of the eukaryotic exosome
S Lykke-Andersen, DE Brodersen… - Journal of cell …, 2009 - journals.biologists.com
The exosome is a multi-subunit 3′-5′ exonucleolytic complex that is conserved in
structure and function in all eukaryotes studied to date. The complex is present in both the …
structure and function in all eukaryotes studied to date. The complex is present in both the …
[HTML][HTML] The yeast exosome functions as a macromolecular cage to channel RNA substrates for degradation
F Bonneau, J Basquin, J Ebert, E Lorentzen, E Conti - Cell, 2009 - cell.com
The exosome is a conserved macromolecular complex essential for RNA degradation. The
nine-subunit core of the eukaryotic exosome shares a similar barrel-like architecture with …
nine-subunit core of the eukaryotic exosome shares a similar barrel-like architecture with …
Reconstitution, activities, and structure of the eukaryotic RNA exosome
The RNA exosome is a multisubunit 3′ to 5′ exoribonuclease complex that participates in
degradation and processing of cellular RNA. To determine the activities and structure of the …
degradation and processing of cellular RNA. To determine the activities and structure of the …
A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response
M Blasius, SA Wagner, C Choudhary… - Genes & …, 2014 - genesdev.cshlp.org
RNA metabolism is altered following DNA damage, but the underlying mechanisms are not
well understood. Through a 14-3-3 interaction screen for DNA damage-induced protein …
well understood. Through a 14-3-3 interaction screen for DNA damage-induced protein …
RNA decay machines: the exosome
A Chlebowski, M Lubas, TH Jensen… - Biochimica et Biophysica …, 2013 - Elsevier
The multisubunit RNA exosome complex is a major ribonuclease of eukaryotic cells that
participates in the processing, quality control and degradation of virtually all classes of RNA …
participates in the processing, quality control and degradation of virtually all classes of RNA …
The RNA exosome nuclease complex regulates human embryonic stem cell differentiation
A defining feature of embryonic stem cells (ESCs) is the ability to differentiate into all three
germ layers. Pluripotency is maintained in part by a unique transcription network that …
germ layers. Pluripotency is maintained in part by a unique transcription network that …
DGCR8 acts as an adaptor for the exosome complex to degrade double-stranded structured RNAs
Summary The Microprocessor complex (DGCR8/Drosha) is required for microRNA (miRNA)
biogenesis but also binds and regulates the stability of several types of cellular RNAs. Of …
biogenesis but also binds and regulates the stability of several types of cellular RNAs. Of …
Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy
The exosome complex is the most important RNA processing machinery within the cell.
Mutations in its subunits EXOSC8 and EXOSC3 cause pontocerebellar hypoplasia, spinal …
Mutations in its subunits EXOSC8 and EXOSC3 cause pontocerebellar hypoplasia, spinal …
EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
J Domingo-Prim, M Endara-Coll, F Bonath… - Nature …, 2019 - nature.com
The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism.
Here we show that the exosome is necessary for the repair of DNA double-strand breaks …
Here we show that the exosome is necessary for the repair of DNA double-strand breaks …