G-Quadruplex DNA has been recognized as a highly appealing target for the development
of new selective chemotherapeutics, which could result in markedly reduced toxicity toward …

Design and optimization of quadruplex-specific small molecules is developing into an
attractive strategy for anti-cancer therapeutics with some promising candidates in clinical …

A variety of cyanines provide versatile and sensitive agents acting as DNA stains and
sensors and have been structurally modified to bind in the DNA minor groove in a sequence …

A G-quadruplex (quadruplex) is a nucleic acid secondary structure adopted by guanine-rich
sequences and is considered to be relevant to various pharmacological and biological …

A series of bisaryldiketene derivatives were designed and synthesized as a new class of
specific G-quadruplex ligands. The ligand–quadruplex interactions were further evaluated …

In the search for new molecular scaffolds for G-quadruplex DNA targeting, we prepared a
pentacyclic, crescent-shaped, benzimidazopyridoquinoxaline derivative, which proved to …

Currently, G-quadruplex structure targeting strategies are considered as a promising
anticancer approach. The purpose of this research is to expand the options for G-quadruplex …

Anthraquinone‐based compounds are well‐known as duplex DNA as well as G‐quadruplex
DNA binders. Implications of various anthraquinone derivatives for specific recognition of G …

AG‐quadruplex is a nucleic acid secondary structure that is adopted by guanine‐rich
sequences, and is considered to be relevant in various pharmacological and biological …

Background G-quadruplexes are promising therapeutic targets for small molecules. In
general, the introduction of steady positive charges through the in situ alkylation of nitrogen …