Influence of age or circadian time on bcl-2 and bax mRNA expression in the rat hippocampus after corticosterone exposure

A Yoshimura, A Masui, S Jinde, H Kanai, N Kato… - Brain research …, 2007 - Elsevier
A rapid elevation in the level of endogenous corticosterone (CORT) functions in the stress
response associated with the hypothalamus–pituitary–adrenal axis, and it has been well …

Corticosterone differentially regulates bax, bcl-2 and bcl-x mRNA levels in the rat hippocampus

SP Cardenas, C Parra, J Bravo, P Morales, HE Lara… - Neuroscience …, 2002 - Elsevier
It has previously been shown that adrenalectomy (ADX) produces apoptosis in the granule
cell of the dentate gyrus (DG), and that this effect is prevented by corticosterone …

Corticosterone impairs hippocampal neuronal calcium regulation—possible mediating mechanisms

EM Elliott, RM Sapolsky - Brain research, 1993 - Elsevier
Corticosterone (CORT), the predominant glucocorticoid of rats which is secreted during
stress, increases hippocampal neuronal vulnerability to excitotoxins, hypoxia-ischemia, and …

Similar effects of aging and corticosterone treatment on mouse hippocampal function

M Talmi, E Carlier, B Soumireu-Mourat - Neurobiology of aging, 1993 - Elsevier
Cumulative exposure to corticosterone (CORT) during the lifespan plays an important role in
the hippocampal aging process, and similar disturbances have been observed in chronic …

Chronic corticosterone affects brain weight, and mitochondrial, but not glial volume fraction in hippocampal area CA3

PS Coburn-Litvak, DA Tata, HE Gorby, DP McCloskey… - Neuroscience, 2004 - Elsevier
Corticosterone (CORT), the predominant glucocorticoid in rodents, is known to damage
hippocampal area CA3. Here we investigate how that damage is represented at the cellular …

Aging increases basal but not stress-induced levels of corticosterone in the brain of the awake rat

P Garrido, M de Blas, A Del Arco, G Segovia… - Neurobiology of …, 2012 - Elsevier
The main purpose of this study was to evaluate the effect of aging on plasma and free
corticosterone (CORT) levels in the brain (hippocampus and prefrontal cortex) in basal …

Attenuating corticosterone levels on the day of memory assessment prevents chronic stress‐induced impairments in spatial memory

RL Wright, EN Lightner, JS Harman… - European Journal of …, 2006 - Wiley Online Library
This study investigated whether chronic stress‐induced spatial memory deficits were caused
by changes in the hypothalamic‐pituitary‐adrenal axis, such as corticosterone (CORT) …

Intrahippocampal corticosterone response in mice selectively bred for extremes in stress reactivity: a microdialysis study

JM Heinzmann, CK Thoeringer… - Journal of …, 2010 - Wiley Online Library
The hypothalamic‐pituitary‐adrenocortical (HPA) axis is one of the major stress hormone
systems, and glucocorticoids (GCs) play a pivotal role in homeostatic processes throughout …

Chronic corticosterone administration from adolescence through early adulthood attenuates depression-like behaviors in mice

Z Xu, Y Zhang, B Hou, Y Gao, Y Wu, C Zhang - Journal of affective …, 2011 - Elsevier
There is evidence that depression may have a different neural basis at different ages.
Although chronic stress and elevated glucocorticoid levels have been demonstrated to lead …

Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging

KC Chen, EM Blalock, MA Curran-Rauhut… - …, 2013 - academic.oup.com
Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus,
their chronic regulatory functions remain poorly understood. Moreover, evidence is …