Background: The pathoetiology of systemic lupus erythematosus (SLE) involves a
multifactorial interaction consisting of various genetic, epigenetic, and environmental factors …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by an
aberrant immune response and persistent inflammation. Its pathogenesis remains unknown; …

Objective Lupus flares occur when genetically predisposed individuals encounter
appropriate environmental agents. Current evidence indicates that the environment …

Introduction DNA hypomethylation in patients with systemic lupus erythematosus (SLE) has
been recently documented in the literature. Low levels of DNA methylation have been …

Objective Hypomethylation of CD40-ligand (CD40L) in T-cells is associated with increased
disease activity in systemic lupus erythematosus (SLE). We therefore investigated possible …

The term 'epigenetics' refers to a series of meiotically/mitotically inheritable alterations in
gene expression, related to environmental factors, without disruption on DNA sequences of …

Background Traditionally, the diagnosis and monitoring of disease activity in systemic lupus
erythematosus (SLE) are contingent upon clinical manifestations and serological markers …

SLE is a complex autoimmune disease that results from the interplay of genetics,
epigenetics and environmental exposures. DNA methylation is an epigenetic mechanism …

Systemic lupus erythematosus (SLE) is an autoimmune disease with multiple organ
involvement. It is characterized by abundant autoantibodies that form immune complex with …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease facilitated by
aberrant immune responses directed against cells and tissues, resulting in inflammation and …