Seeing the forest through the trees: a systematic review of the safety and efficacy of combination chemotherapies used in the treatment of metastatic colorectal cancer
T Bekaii-Saab, C Wu - Critical reviews in oncology/hematology, 2014 - Elsevier
Combinations of fluoropyrimidines with oxaliplatin or irinotecan plus a biologic agent are
standard treatments for metastatic colorectal cancer (mCRC). Recent approvals of first-line …
standard treatments for metastatic colorectal cancer (mCRC). Recent approvals of first-line …
Does the chemotherapy backbone impact on the efficacy of targeted agents in metastatic colorectal cancer? A systematic review and meta-analysis of the literature
Importance The EGFR inhibitors (EGFR-I) cetuximab and panitumumab and the
angiogenesis inhibitors (AIs) bevacizumab and aflibercept have demonstrated varying …
angiogenesis inhibitors (AIs) bevacizumab and aflibercept have demonstrated varying …
Metastatic colorectal cancer: current systemic treatment options
RE Board, JW Valle - Drugs, 2007 - Springer
The treatment of colorectal cancer has become increasingly complex over recent years. With
the emergence of new chemotherapy drugs and targeted agents, there has been great …
the emergence of new chemotherapy drugs and targeted agents, there has been great …
An update on treatment advances for the first-line therapy of metastatic colorectal cancer
JJ Lee, E Chu - The Cancer Journal, 2007 - journals.lww.com
The treatment of metastatic colorectal cancer (mCRC) has evolved significantly over the past
10 years. For nearly 40 years, the fluoropyrimidine 5-fluorouracil (5-FU) was the only agent …
10 years. For nearly 40 years, the fluoropyrimidine 5-fluorouracil (5-FU) was the only agent …
A comprehensive review of sequencing and combination strategies of targeted agents in metastatic colorectal cancer
KK Ciombor, T Bekaii‐Saab - The oncologist, 2018 - academic.oup.com
The emergence of targeted therapies for the treatment of metastatic colorectal cancer
(mCRC) has considerably improved survival, but has also resulted in a dilemma of …
(mCRC) has considerably improved survival, but has also resulted in a dilemma of …
Vascular endothelial growth factor plus epidermal growth factor receptor dual targeted therapy in metastatic colorectal cancer: Synergy or antagonism?
JL Marshall - Journal of Oncology, 2009 - Wiley Online Library
There has been an intensive effort to develop novel therapies for the treatment of metastatic
colorectal cancer (mCRC). The anti‐epidermal growth factor receptor (EGFR) antibodies …
colorectal cancer (mCRC). The anti‐epidermal growth factor receptor (EGFR) antibodies …
Biologic therapies in the metastatic colorectal cancer treatment continuum–applying current evidence to clinical practice
M Peeters, T Price - Cancer treatment reviews, 2012 - Elsevier
More therapeutic options are now available than ever before for patients with metastatic
colorectal cancer (mCRC) and, as such, treatment decisions have become more complex. A …
colorectal cancer (mCRC) and, as such, treatment decisions have become more complex. A …
Systemic therapy for metastatic colorectal cancer: current options, current evidence
H Kelly, RM Goldberg - Journal of Clinical Oncology, 2005 - ascopubs.org
Combination chemotherapy regimens including irinotecan and oxaliplatin markedly improve
response rate and prolong median survival over fluorouracil with leucovorin (FU/LV), and …
response rate and prolong median survival over fluorouracil with leucovorin (FU/LV), and …
Targeting metastatic colorectal cancer–present and emerging treatment options
KK Ciombor, J Berlin - Pharmacogenomics and Personalized …, 2014 - Taylor & Francis
Metastatic colorectal cancer is a significant cause of morbidity and mortality in the US and
around the world. While several novel cytotoxic and biologic therapies have been …
around the world. While several novel cytotoxic and biologic therapies have been …
First-line treatment in metastatic colorectal cancer: Important or crucial?
First-line therapy for metastatic colorectal cancer (mCRC) with fluorouracil plus folinic acid in
combination with irinotecan (FOLFIRI) or oxaliplatin (FOLFOX) is an established standard of …
combination with irinotecan (FOLFIRI) or oxaliplatin (FOLFOX) is an established standard of …