Increased serum levels of endogenous as well as exogenous estrogen are regarded to be
responsible for acquired activated protein C (APC) resistance. It was the objective of this …

Although the use of oral contraceptives has been frequently associated with an increased
risk of thromboembolic events, definitive prothrombotic mechanisms have not so far been …

Oestrogen has been pointed out as a pre-thrombotic factor. Protein C is a key enzyme in the
down-regulation of blood coagulation. Recent data suggest that activated protein C (APC) …

Recent studies have shown that hormone therapy (HT) is associated with an acquired
resistance to activated protein C (APC). The aims of the present study were to evaluate a …

BACKGROUND: The risk of venous tromboembolism (VTE) in women taking combined oral
contraceptives (COCs) is attributed to changes in coagulation and fibrinolysis. The impact of …

Recent concern about the safety of combined oral contraceptives (OCs) with third-
generation progestagens prompted an examination of data from a population-based case …

We investigated whether the occurrence of venous thrombosis in young women who use
oral contraceptives might be explained by the factor V Leiden mutation, which leads to …

Sir—We are pleased that 5 years after the first studies, RMC Herings and colleagues (July
10, p 127) 1 have confirmed the difference in venous thromboembolism risk between …

Objective—Activated protein C (APC) resistance not related to the factor V Leiden mutation
is a risk factor for venous thrombosis. Oral estrogen replacement therapy (ERT) has been …

Background The evaluation of the activated protein C resistance (APCr) based on the
endogenous thrombin potential (ETP) is recommended during the development of steroid …