High-dimensional immune profiling identifies a biomarker to monitor dimethyl fumarate response in multiple sclerosis

M Diebold, E Galli, A Kopf… - Proceedings of the …, 2022 - National Acad Sciences
Dimethyl fumarate (DMF) is an immunomodulatory treatment for multiple sclerosis (MS).
Despite its wide clinical use, the mechanisms underlying clinical response are not …

The NRF 2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis

A Hammer, A Waschbisch… - Annals of clinical …, 2018 - Wiley Online Library
Objective Immunological studies have demonstrated a plethora of beneficial effects of
dimethyl fumarate (DMF) on various cell types. However, the cellular and molecular targets …

Immunological predictors of dimethyl fumarate‐induced lymphopenia

M Diebold, E Galli, A Kopf, N Sanderson… - Annals of …, 2022 - Wiley Online Library
Treatment with dimethyl fumarate (DMF) leads to lymphopenia and infectious complications
in a subset of patients with multiple sclerosis (MS). Here, we aimed to reveal immune …

[HTML][HTML] Dimethyl fumarate treatment in relapsing remitting MS changes the inflammatory CSF protein profile by a prominent decrease in T-helper 1 immunity

S Hojjati, J Ernerudh, M Vrethem, J Mellergård… - Multiple Sclerosis and …, 2023 - Elsevier
Background Dimethyl fumarate (DMF) is a common treatment for multiple sclerosis (MS), but
its mechanisms of action are not fully understood. Targeted proteomics offers insights into …

Low serum neurofilament light chain values identify optimal responders to dimethyl fumarate in multiple sclerosis treatment

PE Walo-Delgado, S Sainz de la Maza, N Villarrubia… - Scientific Reports, 2021 - nature.com
Serum neurofilament light chains (sNfL) are biomarkers of disease activity in multiple
sclerosis (MS), but their value to predict response to treatment, and their association with …

Optimal response to dimethyl fumarate is mediated by a reduction of Th1‐like Th17 cells after 3 months of treatment

MJ Mansilla, J Navarro‐Barriuso… - CNS neuroscience & …, 2019 - Wiley Online Library
Aim Dimethyl fumarate (DMF) is one of the most promising therapies for relapsing‐remitting
multiple sclerosis (RRMS) patients since it has shown immunomodulatory and …

Optimal response to dimethyl fumarate associates in MS with a shift from an inflammatory to a tolerogenic blood cell profile

S Medina, N Villarrubia… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Background: The precise mechanism of action of dimethyl fumarate (DMF) treatment in MS
remains unknown. Objective: To identify the changes in the blood lymphocyte profile of MS …

Dimethyl fumarate treatment shifts the immune environment toward an anti-inflammatory cell profile while maintaining protective humoral immunity

EE Longbrake, Y Mao-Draayer… - Multiple Sclerosis …, 2021 - journals.sagepub.com
Background: Delayed-release dimethyl fumarate (DMF) demonstrates sustained efficacy
and safety for relapsing forms of MS. Absolute lymphocyte count (ALC) is reduced initially …

Dimethyl fumarate therapy reduces memory T cells and the CNS migration potential in patients with multiple sclerosis

RH Hansen, HH Chow, JR Christensen… - Multiple sclerosis and …, 2020 - Elsevier
Background Dimethyl fumarate (DMF) is a disease-modifying therapy for patients with
relapsing-remitting multiple sclerosis (RRMS). T cells are major contributors to the …

Emerging understanding of the mechanism of action for dimethyl fumarate in the treatment of multiple sclerosis

EA Mills, MA Ogrodnik, A Plave… - Frontiers in neurology, 2018 - frontiersin.org
Dimethyl fumarate (DMF) is an effective treatment option for relapsing–remitting multiple
sclerosis (MS), but its therapeutic mechanism of action has not been fully elucidated. A …