High-dimensional immune profiling identifies a biomarker to monitor dimethyl fumarate response in multiple sclerosis
Dimethyl fumarate (DMF) is an immunomodulatory treatment for multiple sclerosis (MS).
Despite its wide clinical use, the mechanisms underlying clinical response are not …
Despite its wide clinical use, the mechanisms underlying clinical response are not …
The NRF 2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis
A Hammer, A Waschbisch… - Annals of clinical …, 2018 - Wiley Online Library
Objective Immunological studies have demonstrated a plethora of beneficial effects of
dimethyl fumarate (DMF) on various cell types. However, the cellular and molecular targets …
dimethyl fumarate (DMF) on various cell types. However, the cellular and molecular targets …
Immunological predictors of dimethyl fumarate‐induced lymphopenia
Treatment with dimethyl fumarate (DMF) leads to lymphopenia and infectious complications
in a subset of patients with multiple sclerosis (MS). Here, we aimed to reveal immune …
in a subset of patients with multiple sclerosis (MS). Here, we aimed to reveal immune …
[HTML][HTML] Dimethyl fumarate treatment in relapsing remitting MS changes the inflammatory CSF protein profile by a prominent decrease in T-helper 1 immunity
S Hojjati, J Ernerudh, M Vrethem, J Mellergård… - Multiple Sclerosis and …, 2023 - Elsevier
Background Dimethyl fumarate (DMF) is a common treatment for multiple sclerosis (MS), but
its mechanisms of action are not fully understood. Targeted proteomics offers insights into …
its mechanisms of action are not fully understood. Targeted proteomics offers insights into …
Low serum neurofilament light chain values identify optimal responders to dimethyl fumarate in multiple sclerosis treatment
PE Walo-Delgado, S Sainz de la Maza, N Villarrubia… - Scientific Reports, 2021 - nature.com
Serum neurofilament light chains (sNfL) are biomarkers of disease activity in multiple
sclerosis (MS), but their value to predict response to treatment, and their association with …
sclerosis (MS), but their value to predict response to treatment, and their association with …
Optimal response to dimethyl fumarate is mediated by a reduction of Th1‐like Th17 cells after 3 months of treatment
MJ Mansilla, J Navarro‐Barriuso… - CNS neuroscience & …, 2019 - Wiley Online Library
Aim Dimethyl fumarate (DMF) is one of the most promising therapies for relapsing‐remitting
multiple sclerosis (RRMS) patients since it has shown immunomodulatory and …
multiple sclerosis (RRMS) patients since it has shown immunomodulatory and …
Optimal response to dimethyl fumarate associates in MS with a shift from an inflammatory to a tolerogenic blood cell profile
S Medina, N Villarrubia… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Background: The precise mechanism of action of dimethyl fumarate (DMF) treatment in MS
remains unknown. Objective: To identify the changes in the blood lymphocyte profile of MS …
remains unknown. Objective: To identify the changes in the blood lymphocyte profile of MS …
Dimethyl fumarate treatment shifts the immune environment toward an anti-inflammatory cell profile while maintaining protective humoral immunity
EE Longbrake, Y Mao-Draayer… - Multiple Sclerosis …, 2021 - journals.sagepub.com
Background: Delayed-release dimethyl fumarate (DMF) demonstrates sustained efficacy
and safety for relapsing forms of MS. Absolute lymphocyte count (ALC) is reduced initially …
and safety for relapsing forms of MS. Absolute lymphocyte count (ALC) is reduced initially …
Dimethyl fumarate therapy reduces memory T cells and the CNS migration potential in patients with multiple sclerosis
RH Hansen, HH Chow, JR Christensen… - Multiple sclerosis and …, 2020 - Elsevier
Background Dimethyl fumarate (DMF) is a disease-modifying therapy for patients with
relapsing-remitting multiple sclerosis (RRMS). T cells are major contributors to the …
relapsing-remitting multiple sclerosis (RRMS). T cells are major contributors to the …
Emerging understanding of the mechanism of action for dimethyl fumarate in the treatment of multiple sclerosis
EA Mills, MA Ogrodnik, A Plave… - Frontiers in neurology, 2018 - frontiersin.org
Dimethyl fumarate (DMF) is an effective treatment option for relapsing–remitting multiple
sclerosis (MS), but its therapeutic mechanism of action has not been fully elucidated. A …
sclerosis (MS), but its therapeutic mechanism of action has not been fully elucidated. A …