Pyrazolines are five-membered heterocyclic compounds containing two nitrogen atoms that
represent a privileged scaffold for various bioactive compounds with diverse …

Depression is one of the key conditions addressed by the Mental Health Gap Action
Programme (mhGAP) of WHO that can lead to self-harm and suicide. Depression is …

Background: Pyrazoline scaffold is a key structural motif found among pharmaceutically
active molecules including synthetic and natural products. The molecules with pyrazoline …

Pyrazolines remain privileged heterocycles in drug discovery. 2-Pyrazoline scaffold has
been proven as a ubiquitous motif which is present in a number of pharmacologically …

Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …

The pyrazoline scaffold plays a vital role in heterocyclic chemistry as a fundamental building
block in both organic and medicinal chemistry. A pyrazoline scaffold is composed of an …

In the five membered nitrogen containing heterocyclic family, pyrazoline could be
recognized as a promising scaffold for the inhibition of Monoamine oxidase. Substitution at …

It has been established that pyrazolines and their analogs are pharmacologically active
scaffolds. The pyrazoline moiety is present in several marketed molecules with a wide range …

Introduction: Chalcones are one of the major classes of naturally occurring compounds and
have a vast significance in medicinal chemistry, presenting with a wide scope of …

Among different heterocyclic chemotypes incorporating two nitrogen atoms, pyrazolines
could be considered a valid pharmacophore for the synthesis of selective monoamine …