Biosynthesis of pigment melanin in pigment cells (melanocytes, nevus cells, melanoma
cells) constitutes a distinctive but integrated part of intracellular metabolism. Although the …

Historically, our concept of melanogenesis developed from the early observation of
Bourquelot and Bertrand (1) that tyrosinase was able to effect the oxidative conversion of …

The occurrence of high amounts of dopa has been demonstrated chemically in the piliary
system of pigmented animals (guinea‐pig, rabbit, and dog). Histochemically, a …

Melanin biosynthesis involves the enzymatic conversion of tyrosine, via
dihydroxyphenylalanine (dopa), to melanin through a number of intermediate steps. It is …

Deposition of Melanin in Sparrow Bill Following Local Action of Testosterone Propionate in
Alcoholic Solution. Page 1 MELANIN AND LOCAL ANDROGEN APPLICATION 649 …

Autochthonous Formation of Melanin in Mesodermal Cells * Page 1 144 M eirowsky, Free man
avait d’abord appelé en 1894 «epitelioma excrecente seudo-inílamatorio» puis, plus tard, avec …

At the turn of the century two French investigators, Bertrand & Bour quelot (1, 2), showed that
a plant enzyme which they named tyrosinase could catalyze the oxidation of the amino acid …

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Bloch, as a result of his discovery of the “dopa reaction” and because it had been impossible
to demonstrate tyrosinase in the skin of any of the slightly pigmented vertebrates, postulated …

Tyrosinase [EC 1. 10. 3. 1, o-diphenol: 02 oxidoreduetase] is responsible for melanin
formation in mammalian melanocyte. In mouse melanoma tyrosinase has been reported to …