Type 2 diabetes mellitus is characterized by insulin resistance and failure of pancreatic β-
cells producing insulin. Autophagy plays a crucial role in cellular homeostasis through …

Autophagy plays a crucial role in cellular homeostasis through the degradation and
recycling of organelles such as mitochondria or endoplasmic reticulum (ER) that are closely …

Diabetes mellitus is characterized by decreased insulin secretion and action. Decreased
insulin secretion results from a reduction in pancreatic β-cell mass and function. Apoptosis …

Autophagy is a cellular degradation-recycling system for aggregated proteins and damaged
organelles. Although dysregulated autophagy is implicated in various diseases including …

Type 2 diabetes mellitus is characterized by insulin resistance and failure of pancreatic β‐
cells producing insulin. Mitochondrial dysfunction may play a role in both processes of …

Autophagy is a membrane-trafficking mechanism that delivers cytoplasmic components into
the lysosome to form autophagic vacuoles for bulk protein degradation. While previous …

Pancreatic β-cells play a key role in glucose homeostasis in mammals. Although large-scale
protein synthesis and degradation occur in pancreatic β-cells, the mechanism underlying …

Type 2 diabetes (T2D) is characterized by decreased insulin secretion and action.
Decreased insulin secretion results from a reduction in pancreatic β‐cell mass and/or …

Autophagy is a major regulator of pancreatic beta cell homeostasis. Altered autophagic
activity has been implicated in the beta cells of patients with type 2 diabetes, and in the beta …

Autophagy is a conserved system for the degradation of cytoplasmic proteins and
organelles. During insulin resistance, in which insulin secretion is enhanced and β-cell …