CD4+ T-cells facilitate wound healing post-myocardial infarction (MI) but promote left-
ventricular (LV) remodeling during ischemic heart failure (HF; 8 weeks post-MI). Therefore, it …

The adaptive immune response is key for cardiac wound healing post-myocardial infarction
(MI) despite low T-cell numbers. We hypothesized that CD8+ T-cells regulate the …

Summary Downregulation of CD4+ CD25+ regulatory T lymphocytes (Treg) has been found
in local atherosclerotic lesions and in patients with myocardial infarction (MI). However, the …

Background—Inappropriately sustained inflammation is a hallmark of chronic ischemic heart
failure (HF); however, the pathophysiological role of T lymphocytes is unclear. Methods and …

Background—The role of adaptive immunity, especially CD4+ T-helper cells, has not yet
been systematically investigated in wound healing and remodeling after myocardial …

Background: In the past years, several studies investigated how distinct immune cell subsets
affects post–myocardial infarction repair. However, whether and how the tissue environment …

A large body of evidence produced during decades of research indicates that myocardial
injury activates innate immunity. On the one hand, innate immunity both aggravates …

Myocardial infarction (MI) is a common condition responsible for mortality and morbidity
related to ischemic heart failure. Accumulating experimental and translational evidence …

Ischemic injury to the heart causes cardiomyocyte and supportive tissue death that result in
adverse remodeling and formation of scar tissue at the site of injury. The dying cardiac tissue …

Myocardial inflammation can lead to lethal acute or chronic heart failure (HF). T lymphocytes
(T cells), have been reported in the inflamed heart in different etiologies of HF, and more …