Since the description of the first case of sickle cell disease (SCD) in 1910 by James Herrick
and Ernest Irons, much has been learned about the disorder and improvements in care have …

Sickle cell disease (SCD) is the name for a group of genetic blood disorders caused by
sickle hemoglobin (Hb S). The 2 key features of SCD are chronic hemolytic anemia and …

Background Sickle cell disease (SCD) is a common, severe disorder that includes
congenital hemolytic anemias caused by inherited point mutations in the β-globin gene. 1 …

Sickle cell disease (SCD) is a serious and life-threatening disease that affects approximately
1 in 600 African Americans [1, 2]. In 1910, Herrick described the first patient with SCD, and …

Sickle cell disease (SCD) is a heterogeneous inherited disorder of hemoglobin that causes
chronic hemolytic anemia, vaso-occlusion, and endothelial dysfunction. These physiologic …

Thirty years ago, the first major federal legislation concerning sickle cell disease treatment
was passed, resulting in the development of comprehensive sickle cell centers. We are now …

Sickle cell disease represents a spectrum of inherited hemoglobin disorders. The
pathophysiology involves abnormalities not just in red blood cells but also vascular …

Efforts to enhance therapy for children and adults with sickle cell disease (SCD) have
proven more challenging than might have been predicted from the fact that an …

Sickle cell disease (SCD) is a group of complex genetic disorders with multisystem
manifestations. This statement provides pediatricians in primary care and subspecialty …

OBJECTIVE: Sickle cell disease (SCD) affects 70 000 to 100 000 people in the United
States, and 2000 infants are born with the disease each year. The purpose of this study was …