Abstract β-Hydroxy-β-methylglutaryl coA reductase inhibitors (HRIs) inhibit isoprenylation of
several members of the Ras superfamily of proteins and therefore have important cellular …

The cholesterol-lowering medications, statins, inhibit cellular proliferation and induce
apoptosis in an array of cancer cell lines, including melanoma. We investigated the …

The statin family of drugs inhibits 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, the
rate-limiting enzyme of the mevalonate pathway, and is used clinically as a safe and …

Lovastatin is an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)
reductase, the major regulatory enzyme of the mevalonate pathway. We have previously …

The statin family of drugs are well-established inhibitors of 3-hydroxy-3-methylglutaryl-CoA
reductase and are used clinically in the control of hypercholesterolemia. Recent evidence …

We earlier showed that lovastatin potentiated the chemopreventive effects of sulindac
against colon neoplasia in a rodent model and augments apoptosis induced by 5-FU and …

Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase is the rate-limiting enzyme of the
mevalonate pathway, the diverse array of end products of which are vital for a variety of …

The statin family of drugs target HMG-CoA reductase, the rate-limiting enzyme of the
mevalonate pathway, and have been used successfully in the treatment of …

The hydroxymethylglutaryl-CoA reductase inhibitor lovastatin is used widely to treat
hypercholesterolemia and has been shown to have cell cycle-specific effects. In these …

Abstract The statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) have
been proven to be effective in lowering cholesterol and as anti-lipid agents against …