The microsomal triglyceride transfer protein facilitates assembly and secretion of apolipoprotein B-containing lipoproteins and decreases cotranslational degradation …
We studied the role of microsomal triglyceride transfer protein (MTP) in the synthesis,
secretion, and cotranslational degradation of apolipoprotein (apo) B using nonhepatic COS …
secretion, and cotranslational degradation of apolipoprotein (apo) B using nonhepatic COS …
Microsomal triglyceride transfer protein binding and lipid transfer activities are independent of each other, but both are required for secretion of apolipoprotein B …
J Liang, HN Ginsberg - Journal of Biological Chemistry, 2001 - ASBMB
Recent studies indicate that microsomal triglyceride transfer protein (MTP) and
apolipoprotein B (apoB) interact physically via two specific binding sites located within the …
apolipoprotein B (apoB) interact physically via two specific binding sites located within the …
Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the …
DA Gordon, H Jamil, RE Gregg, SO Olofsson… - Journal of Biological …, 1996 - ASBMB
The microsomal triglyceride transfer protein (MTP) is required for assembly and secretion of
the lipoproteins containing apolipoprotein B (apoB): very low density lipoproteins and …
the lipoproteins containing apolipoprotein B (apoB): very low density lipoproteins and …
Identification of domains in apolipoprotein B100 that confer a high requirement for the microsomal triglyceride transfer protein
The microsomal triglyceride transfer protein (MTP) is required for the assembly and
secretion of apoB-containing lipoproteins. To investigate the role of MTP in lipoprotein …
secretion of apoB-containing lipoproteins. To investigate the role of MTP in lipoprotein …
Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by …
DA Gordon, H Jamil, D Sharp… - Proceedings of the …, 1994 - National Acad Sciences
To elucidate the role of the microsomal triglyceride transfer protein (MTP) in lipoprotein
assembly, MTP and apolipoprotein B-53 (apoB 53; the N-terminal 53% of apoB) were …
assembly, MTP and apolipoprotein B-53 (apoB 53; the N-terminal 53% of apoB) were …
Interactions between microsomal triglyceride transfer protein and apolipoprotein B within the endoplasmic reticulum in a heterologous expression system
SB Patel, SM Grundy - Journal of Biological Chemistry, 1996 - ASBMB
When apolipoprotein B (apoB) is expressed in heterologous cells, it is not secreted but
retained and degraded within the endoplasmic reticulum (ER). We have previously …
retained and degraded within the endoplasmic reticulum (ER). We have previously …
Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B-containing lipoproteins from heterologous …
JM Leiper, JD Bayliss, RJ Pease, DJ Brett… - Journal of Biological …, 1994 - ASBMB
Apolipoprotein (apo) B is an obligatory component of triglyceride-rich lipoproteins. In the
rare autosomal recessive disorder abetalipoproteinemia (ABL), no triglyceride-rich …
rare autosomal recessive disorder abetalipoproteinemia (ABL), no triglyceride-rich …
Binding of microsomal triglyceride transfer protein to lipids results in increased affinity for apolipoprotein B: evidence for stable microsomal MTP-lipid complexes
A Bakillah, MM Hussain - Journal of Biological Chemistry, 2001 - ASBMB
Apolipoprotein B (apoB) and microsomal triglyceride transfer protein (MTP) are known to
interact with each other. We evaluated the effect of different lipids on the protein-protein …
interact with each other. We evaluated the effect of different lipids on the protein-protein …
Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly
DA Gordon, H Jamil - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2000 - Elsevier
The microsomal triglyceride transfer protein (MTP) is necessary for the proper assembly of
the apolipoprotein B containing lipoproteins, very low density lipoprotein and chylomicrons …
the apolipoprotein B containing lipoproteins, very low density lipoprotein and chylomicrons …
Normal activity of microsomal triglyceride transfer protein is required for the oleate-induced secretion of very low density lipoproteins containing apolipoprotein B from …
The requirement of the activity of microsomal triglyceride transfer protein (MTP) for very low
density lipoprotein (VLDL) secretion was determined using McA-RH7777 cells stably …
density lipoprotein (VLDL) secretion was determined using McA-RH7777 cells stably …