Extracellular HSPA1A promotes the growth of hepatocarcinoma by augmenting tumor cell proliferation and apoptosis-resistance
FH Wu, Y Yuan, D Li, SJ Liao, B Yan, JJ Wei, YH Zhou… - Cancer letters, 2012 - Elsevier
Intracellular HSP70 has been implicated as a cytoprotective protein, whereas the effect of
extracellular HSP70 on tumor cells has not been fully understood to date. Here we report …
extracellular HSP70 on tumor cells has not been fully understood to date. Here we report …
[HTML][HTML] The expression profiles and prognostic values of HSP70s in hepatocellular carcinoma
B Wang, T Lan, H Xiao, ZH Chen, C Wei, LF Chen… - Cancer cell …, 2021 - Springer
Background The HSP70 family of heat shock protein plays a critical role in protein synthesis
and transport to maintain protein homeostasis. Several studies have indicated that HSP70s …
and transport to maintain protein homeostasis. Several studies have indicated that HSP70s …
HSPA4 knockdown retarded progression and development of colorectal cancer
M Zhang, W Dai, Z Li, L Tang, J Chen… - Cancer Management …, 2021 - Taylor & Francis
Purpose Colorectal cancer (CRC) is a common malignancy associated with high morbidity
and mortality. Heat shock 70 kDa protein 4 (HSPA4) has been shown to exert regulatory …
and mortality. Heat shock 70 kDa protein 4 (HSPA4) has been shown to exert regulatory …
[HTML][HTML] Upregulation of HSPA1A/HSPA1B/HSPA7 and downregulation of HSPA9 were related to poor survival in colon cancer
Y Guan, X Zhu, J Liang, M Wei, S Huang… - Frontiers in oncology, 2021 - frontiersin.org
The human HSP70 family is a type of heat shock protein (HSP), consisting of 13 members
encoded by the HSPA genes. HSPs play important roles in regulating cellular responses …
encoded by the HSPA genes. HSPs play important roles in regulating cellular responses …
[HTML][HTML] Functional redundancy of HSPA1, HSPA2 and other HSPA proteins in non-small cell lung carcinoma (NSCLC); an implication for NSCLC treatment
Heat shock proteins (HSPs) are a large group of chaperones considered critical for
maintaining cellular proteostasis. Their aberrant expression in tumors can modulate the …
maintaining cellular proteostasis. Their aberrant expression in tumors can modulate the …
HSPA6 and its role in cancers and other diseases
B Song, S Shen, S Fu, J Fu - Molecular Biology Reports, 2022 - Springer
Abstract Heat Shock Protein Family A (Hsp70) Member 6 (HSPA6)(Online Mendelian
Inheritance in Man: 140555) belongs to the HSP70 family and is a partially conserved …
Inheritance in Man: 140555) belongs to the HSP70 family and is a partially conserved …
[HTML][HTML] Inducible HSP70 antagonizes cisplatin‑induced cell apoptosis through inhibition of the MAPK signaling pathway in HGC‑27 cells
L Sheng, T Tang, Y Liu, Y Ma… - International …, 2018 - spandidos-publications.com
Inducible heat shock protein 70 (HSP70; also known as HSPA1 or HSP72) is implicated in
cancer. As a stress‑inducible heat shock protein, HSP70 is highly expressed in a variety of …
cancer. As a stress‑inducible heat shock protein, HSP70 is highly expressed in a variety of …
Expression of HSPA2 in human hepatocellular carcinoma and its clinical significance
Y Fu, H Zhao, XS Li, HR Kang, JX Ma, FF Yao, N Du - Tumor Biology, 2014 - Springer
Hepatocellular carcinoma (HCC) remains one of the most common cancers worldwide.
HSPA2 has been highlighted as an important marker in many types of cancers. However …
HSPA2 has been highlighted as an important marker in many types of cancers. However …
[HTML][HTML] Expression and clinical significance of HSPA2 in pancreatic ductal adenocarcinoma
H Zhang, H Gao, C Liu, Y Kong, C Wang, H Zhang - Diagnostic pathology, 2015 - Springer
Background It has been shown that heat shock-related 70-kDa protein 2 (HSPA2), a
member of the HSP70 family of heat shock proteins, is important for cancer cell growth and …
member of the HSP70 family of heat shock proteins, is important for cancer cell growth and …
[HTML][HTML] Overexpression of HSPA2 is correlated with poor prognosis in esophageal squamous cell carcinoma
H Zhang, W Chen, CJ Duan, CF Zhang - World journal of surgical oncology, 2013 - Springer
Background Heat shock-related 70 kDa protein 2 (HSPA2) has been identified as a potential
cancer-promoting protein expressed at abnormal levels in a subset of cancers. However, its …
cancer-promoting protein expressed at abnormal levels in a subset of cancers. However, its …