Archaeal histones wrap DNA into complexes, designated archaeal nucleosomes, that
resemble the tetrasome core of a eukaryotic nucleosome. Therefore, all DNA interactions in …

Background Histone wrapping of DNA into nucleosomes almost certainly evolved in the
Archaea, and predates Eukaryotes. In Eukaryotes, nucleosome positioning plays a central …

Histones are ubiquitous in eukaryotes where they assemble into nucleosomes, binding and
wrapping DNA to form chromatin. One process to modify chromatin and regulate DNA …

Histone proteins compact and organize DNA resulting in a dynamic chromatin architecture
impacting DNA accessibility and ultimately gene expression. Eukaryotic chromatin …

Histones are a principal constituent of chromatin in eukaryotes and fundamental to our
understanding of eukaryotic gene regulation. In archaea, histones are widespread but not …

HTz is a member of the archaeal histone family. The archaeal histones have primary
sequences and structural similarity to the eukaryal histone fold domain, and are thought to …

Shuttle vectors that replicate stably and express selectable phenotypes in both
Thermococcus kodakaraensis and Escherichia coli have been constructed. Plasmid pTN1 …

We have applied chromatin sequencing technology to the euryarchaeon Thermococcus
kodakarensis, which is known to possess histone‐like proteins. We detect positioned …

Being distinct from bacteria and eukaryotes, Archaea constitute a third domain of living
things. The DNA replication, transcription, and translation machineries of Archaea are more …

We have recently developed a gene disruption system for the hyperthermophilic archaeon
Thermococcus kodakaraensis by utilizing a pyrF-deficient mutant, KU25, as a host strain and …