Background: Dabigatran etexilate is a new oral anticoagulant for the therapy and
prophylaxis of venous thromboembolism and stroke prevention in patients with atrial …

Warfarin needs to be monitored at least monthly with a blood test known as the prothrombin
time test, most commonly reported as an international normalized ratio (INR). The prescriber …

Background Dabigatran is an alternative to warfarin (WF) for the thromboprophylaxis of
stroke in patients with non-valvular atrial fibrillation (NVAF). The advantage of dabigatran …

Abstract Abstract 22 Background: The objective of this study is to determine the
pharmacokinetics (PK) and pharmacodynamics (PD) of dabigatran (a small molecule …

Dabigatran is an oral, reversible thrombin inhibitor that has shown promising results in large
clinical trials. Laboratory monitoring is not needed but the effects on common coagulation …

Introduction Calibrated automated thrombinography (CAT) is a sensitive method to assess
coagulation. Dabigatran inhibits both free thrombin and the α 2 macroglobulin (α 2 M) …

Abstract Purpose Bosutinib, a dual Src and Abl tyrosine kinase inhibitor for the treatment of
chronic myeloid leukemia, demonstrated concentration-dependent inhibitory effects on P …

Dabigatran is an oral anticoagulant that is increasingly used for atrial fibrillation (AF).
Presently, many authorities state that routine laboratory coagulation monitoring is not …

INTRODUCTION: The new oral anticoagulants are effective alternatives for warfarin but
specific antidotes are not yet available for these agents to manage life-threatening bleeding …

OBJECTIVE: Dabigatran is a nov-el target specific oral anticoagulant for stroke prevention in
non valvular atrial fibrillation. Little is still known about its real-world effectiveness and safety …