Investigations into the etiology of neural tube defects
RM Cabrera, DS Hill, AJ Etheredge… - Birth Defects Research …, 2004 - Wiley Online Library
Neural tube defects (NTDs) are serious malformations affecting approximately 1 per 1000
births, yet the mechanisms by which they arise are unknown. There have been consistent …
births, yet the mechanisms by which they arise are unknown. There have been consistent …
Further evidence for a maternal genetic effect and a sex‐influenced effect contributing to risk for human neural tube defects
KL Deak, DG Siegel, TM George… - … Research Part A …, 2008 - Wiley Online Library
BACKGROUND: Neural tube defects (NTDs), including spina bifida and anencephaly, are
the second most common birth defect with an incidence of 1/1000. Genetic factors are …
the second most common birth defect with an incidence of 1/1000. Genetic factors are …
Pathophysiology, prevention, and potential treatment of neural tube defects
SM Manning, R Jennings… - Mental retardation and …, 2000 - Wiley Online Library
Neural tube defects (NTD) remain a major cause of morbidity in spite of the reduction in
liveborn incidence with periconceptional folic acid. However, the etiology remains unknown …
liveborn incidence with periconceptional folic acid. However, the etiology remains unknown …
The emerging role of epigenetic mechanisms in the etiology of neural tube defects
NDE Greene, P Stanier, GE Moore - Epigenetics, 2011 - Taylor & Francis
The molecular requirements for neural tube closure are complex. This is illustrated by the
occurrence of neural tube defects (NTDs) in many genetic mouse mutants, which implicate a …
occurrence of neural tube defects (NTDs) in many genetic mouse mutants, which implicate a …
Closing in on mechanisms of open neural tube defects
S Lee, JG Gleeson - Trends in neurosciences, 2020 - cell.com
Neural tube defects (NTDs) represent a failure of the neural plate to complete the
developmental transition to a neural tube. NTDs are the most common birth anomaly of the …
developmental transition to a neural tube. NTDs are the most common birth anomaly of the …
Analysis of select folate pathway genes, PAX3, and human T in a midwestern neural tube defect population
D Trembath, AL Sherbondy, DC Vandyke… - …, 1999 - Wiley Online Library
Neural tube defects (NTDs) are a common birth defect, seen in approximately 1/1,000 births
in the United States. NTDs are considered a complex trait where several genes, interacting …
in the United States. NTDs are considered a complex trait where several genes, interacting …
Genetic studies in neural tube defects
EC Melvin, TM George, G Worley, A Franklin… - Pediatric …, 2000 - karger.com
Neural tube defects (NTD) are one of the most common birth defects and are caused by both
environmental and genetic factors. The approach to identifying the genes predisposing to …
environmental and genetic factors. The approach to identifying the genes predisposing to …
[HTML][HTML] Genetic variants in the folate pathway and the risk of neural tube defects: a meta-analysis of the published literature
T Zhang, J Lou, R Zhong, J Wu, L Zou, Y Sun, X Lu… - PLos one, 2013 - journals.plos.org
Background Neural Tube Defects (NTDs) are among the most prevalent and most severe
congenital malformations worldwide. Polymorphisms in key genes involving the folate …
congenital malformations worldwide. Polymorphisms in key genes involving the folate …
Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects?
SG Heil, NMJ Van der Put, ET Waas… - Molecular genetics and …, 2001 - Elsevier
Neural tube defects (NTD) arise in the first weeks of pregnancy due to a combination of
environmental and genetic factors. In mothers of children with NTD elevated homocysteine …
environmental and genetic factors. In mothers of children with NTD elevated homocysteine …
Neural tube defects—disorders of neurulation and related embryonic processes
AJ Copp, NDE Greene - Wiley Interdisciplinary Reviews …, 2013 - Wiley Online Library
Neural tube defects (NTDs) are severe congenital malformations affecting 1 in every 1000
pregnancies.'Open'NTDs result from failure of primary neurulation as seen in anencephaly …
pregnancies.'Open'NTDs result from failure of primary neurulation as seen in anencephaly …