Pharmacogenomics is a rapidly developing field of biomedical research, which investigates
phenotypic and pharmacodynamic consequences of the genetic variations among …

The MDR1 (ABCB1) gene encodes a membrane-bound transporter that actively effluxes a
wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant …

The MDR1 (ABCB1) gene product P-glycoprotein is a membrane protein, which functions as
an ATP-dependent exporter of xenobiotics from cells. Its importance was first recognized …

MDR1 (ABCB1) gene encodes for P-glycoprotein (P-gp, MDR1, ABCB1), an ATP-binding
cassette superfamily member involved in the transport of xenobiotics. Here, we investigated …

There has been an increasing appreciation of the role of drug transporters in the
pharmacokinetic and pharmacodynamic profiles of certain drugs. Among various drug …

The multidrug resistance (MDR1) gene product P-glycoprotein is a membrane protein that
functions as an ATP-dependent efflux pump, transporting exogenous and endogenous …

Purpose P-glycoprotein (P-gp), encoded by MDR1 (or ABCB1), is important in anticancer
drug delivery and resistance. We evaluated alterations in P-gp-mediated transport of …

Abstract P-glycoprotein (ABCB1, MDR1) belongs to the ABC transporter family transporting
a wide range of drugs and xenobiotics from intra-to extracellular at many biological …

ABSTRACT MDR1 gene encodes for P glycoprotein (P-gp), which plays an important role in
bioavailability and cell-toxicity limitation of a wide range of drugs and xenobiotics. Three …

Functional single nucleotide polymorphism (SNP) C3435T in exon 26 of the MDR1 (ABCB1)
gene encoding the xenobiotic transporter P-glycoprotein (P-gp, MDR1, ABCB1) may …