In cytotoxic T cells (CTL), Akt, also known as protein kinase B, is activated by the T cell
antigen receptor (TCR) and the cytokine interleukin 2 (IL-2). Akt can control cell metabolism …

Akt is involved in the regulation of diverse cellular functions such as cell proliferation, energy
metabolism, and apoptosis. Although three Akt isoforms are known, the function of each …

The serine/threonine kinase Akt is an effector of PI3K-generated phosphatidylinositol (3, 4,
5)-trisphosphate [PI (3, 4, 5) P3] and is a principle mediator of growth factor-induced signal …

The regulated elimination of T cells serves to maintain normal immune function and prevents
autoimmune responses. IL-2 family cytokines play an important role in controlling the …

Ten years ago, it was observed that the Akt kinase is activated by phosphorylation via a
phosphoinositide 3-kinase (PI-3K)-dependent process. This discovery generated enormous …

More than a decade after their discovery, the three AKT kinase family members have
emerged as central players in the signaling cascades that regulate cell growth, proliferation …

T cell development and maturation involve a variety of defined and coordinated
developmental stages under the control of a variety of signaling networks. They function as …

Protein Kinase B (PKB), more commonly referred to as Akt, is a serine/threonine-specific
protein kinase. It is well established as a critical signaling node that regulates a myriad of …

Akt isoforms play key roles in multiple cellular processes; however, the roles of Akt-1 and Akt-
2 isoforms in the development of T cell–mediated autoimmunity are poorly defined. In this …

The Akt serine/threonine kinase (also called protein kinase B= PKB) has emerged as a
critical signaling molecule within eukaryotic cells. In addition to work clarifying its regulation …