Single-cell transcriptomics has emerged as a powerful technology to characterise gene
expression within individual cells. Over the last 5 years, as the technology has matured …

Single cell transcriptomics has significantly contributed to our understanding of cell types
across species, organs and developmental processes. The rapid development of …

High‐throughput‐omics techniques have revolutionised biology, allowing for thorough and
unbiased characterisation of the molecular states of biological systems. However, cellular …

The ability to profile hundreds of thousands to millions of single cells using scRNA-
sequencing has revolutionized the fields of cell and developmental biology, providing …

Single cell RNA-sequencing (scRNA-seq) technology has matured to the point that it is
possible to generate large single cell atlases of developing mouse embryos. These atlases …

Single cell analyses encompass multiple approaches that, we suggest, can be summarized
by two unifying goals: to explain the cellular composition of tissues; and to characterize the …

The zygote undergoes five cell divisions prior to the first signs of lineage segregation.
Blastocyst formation requires segregation of the trophectoderm, needed for implantation …

The recent flood of single-cell data not only boosts our knowledge of cells and cell types, but
also provides new insight into development and evolution from a cellular perspective. For …

INTRODUCTION Understanding the differentiation of stem cells into the vast amount of cell
types that form the human body is a central problem of basic and medical science. The …

In recent years, genome-wide profiling approaches have begun to uncover the molecular
programs that drive developmental processes. In particular, technical advances that enable …