Purpose: Family history of prostate cancer is one of the few universally accepted risk factors
for prostate cancer. How much an assessment of inherited polygenic risk for prostate cancer …

Background: Familial prostate cancer risk estimates are inflated by clinically insignificant low-
risk cancer, diagnosed after prostate-specific antigen testing. We provide age-specific …

Background Clinical variables—age, family history, genetics—are used for prostate cancer
risk stratification. Recently, polygenic hazard scores (PHS46, PHS166) were validated as …

Purpose: Breast and prostate cancer co-occur in families, and women with a family history of
prostate cancer are at increased breast cancer risk. Prostate cancer is among the most …

Background: Genome-wide association studies have identified multiple genetic variants
associated with prostate cancer risk which explain a substantial proportion of familial relative …

Genome-wide association studies have detected more than 30 inherited prostate cancer risk
variants. While clearly associated with risk, their relationship with clinical outcome …

Background Genetic scores may provide an objective measure of prostate cancer risk and
thus inform screening decisions. We evaluated whether a polygenic hazard score based on …

Polygenic risk scores (PRSs) for a variety of diseases have recently been shown to have
relative risks that depend on age, and genetic relative risks decrease with increasing age. A …

Genetic factors may be used not only to assess risk of prostate cancer development but also
to evaluate prostate cancer outcomes including clinical prognosis, treatment methods, and …

Polygenic risk scores (PRSs) of common genetic variants have shown promise in prostate
cancer risk stratification, but their validity across populations has yet to be confirmed. We …