BACKGROUND Polygenic risk scores comprising established susceptibility variants have
shown to be informative classifiers for several complex diseases including prostate cancer …

Although prostate cancer is known to have a strong genetic basis and is influenced by both
common and rare variants, the ability to investigate the combined effect of such genetic risk …

Clinical and pathological risk grouping defines management in localized prostate cancer.
Recent work suggests men with high-risk prostate cancer can be further subdivided into …

Prostate cancer heritability is attributed to a combination of rare, moderate to highly
penetrant genetic variants as well as commonly occurring variants conferring modest risks …

Abstract Background: Of the 200,000 US men annually diagnosed with prostate cancer,
approximately 20% to 30% will have clinically aggressive disease. Although factors such as …

Background: Men with familial prostate cancer and African American men are at risk for
developing prostate cancer at younger ages. Genetic markers predicting early-onset …

BACKGROUND Prostate cancer (PC) relative risks (RRs) are typically estimated based on
status of close relatives or presence of any affected relatives. This study provides RR …

Purpose: Genome-wide association studies (GWAS) have identified multiple novel prostate
cancer predisposition loci. Whether these common genetic variants are associated with …

BACKGROUND Familial risks by proband status and age are useful for clinical counseling,
and they can be used to calculate population‐attributable fractions (PAFs), which show the …

PURPOSE: Five genetic variants along chromosomes 8q24 and 17q have a cumulative
association with prostate cancer risk. Our research group previously reported an association …