The prognostic and biological importance of chromatin regulation-related genes for lung cancer is examined using bioinformatics and experimentally confirmed

S Ren, H Yu - Pathology-Research and Practice, 2023 - Elsevier
Background The pathogenesis and clinical diagnosis of lung adenocarcinoma (LUAD), a
malignant illness with substantial morbidity and mortality, are still being investigated. Genes …

Integrated single-cell and transcriptome sequencing analyses determines a chromatin regulator-based signature for evaluating prognosis in lung adenocarcinoma

Q Shi, S Han, X Liu, S Wang, H Ma - Frontiers in oncology, 2022 - frontiersin.org
Background Accumulating evidence has highlighted the significance of chromatin regulator
(CR) in pathogenesis and progression of cancer. However, the prognostic role of CRs in …

Chromatin separation regulators predict the prognosis and immune microenvironment estimation in lung adenocarcinoma

Z Li, Z Ma, H Xue, R Shen, K Qin, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Background: Abnormal chromosome segregation is identified to be a common hallmark of
cancer. However, the specific predictive value of it in lung adenocarcinoma (LUAD) is …

Identification of Prognostic Genes and Immune Landscape Signatures Based on Tumor Microenvironment in Lung Adenocarcinoma

P Han, Y Fan, Q Liu, J Zhou - Disease Markers, 2022 - Wiley Online Library
Background. Lung adenocarcinoma is the most common lung cancer subtype and accounts
for the highest proportion of cancer‐related deaths. The tumor microenvironment influences …

A prognostic signature model for unveiling tumor progression in lung adenocarcinoma

Z Li, T Zeng, C Zhou, Y Chen, W Yin - Frontiers in Oncology, 2022 - frontiersin.org
A more accurate prognosis is important for clinical treatment of lung adenocarcinoma.
However, due to the limitation of sample and technical bias, most prognostic signatures …

Establishing a Novel Gene Signature Related to Histone Modifications for Predicting Prognosis in Lung Adenocarcinoma

M Liu, X Yu, S Xu, C Qu - Journal of Oncology, 2022 - Wiley Online Library
Background. Epigenetic modifications have been revealed to play an important role in
tumorigenesis and tumor development. This study aims to analyze the role of histone …

Integration of multiple key molecules in lung adenocarcinoma identifies prognostic and immunotherapeutic relevant gene signatures

Q Wu, L Wang, H Wei, B Li, J Yang, Z Wang… - International …, 2020 - Elsevier
Background Although multiple key molecules in lung adenocarcinoma (LUAD) have been
identified in recent years, the overall tumor microenvironment (TME) immune cell infiltration …

Identification of four genes as prognosis signatures in lung adenocarcinoma microenvironment

Y Yao, T Zhang, L Qi, R Liu, G Liu, J Li… - Pharmacogenomics and …, 2021 - Taylor & Francis
Background Tumor microenvironment (TME) cells constitute a vital element of tumor tissues.
Increasing evidence has shown that immune response in the microenvironment plays an …

Identification and analysis of prognostic immune cell homeostasis characteristics in lung adenocarcinoma

Y Sun, Q Ma, Y Chen, D Liao… - The Clinical Respiratory …, 2024 - Wiley Online Library
Background Lung adenocarcinoma (LUAD) is one of the most invasive malignant tumor of
the respiratory system. It is also the common pathological type leading to the death of LUAD …

[HTML][HTML] Identification of prognostic candidate signatures by systematically revealing transcriptome characteristics in lung adenocarcinoma with differing tumor …

Q Chen, J Ma, X Wang, X Zhu - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
Accumulated evidence shows that tumor microenvironment plays crucial roles in predicting
clinical outcomes of lung adenocarcinoma (LUAD). The current study aimed to identify some …