Proteins are translated in the cytoplasm, but many need to access the nucleus to perform
their functions. Understanding how these nuclear proteins are transported through the …

Although proteins are translated on cytoplasmic ribosomes, many of these proteins play
essential roles in the nucleus, mediating key cellular processes including but not limited to …

Recent progress indicates that there are multiple pathways of nucleocytoplasmic transport
which involve specific targeting sequences, such as nuclear localization sequences (NLSs) …

The nuclear import of proteins into the cell nucleus involves the recognition of a nuclear
localization signal sequence, borne by the protein to be transported, by complex molecules …

The best understood system for the transport of macromolecules between the cytoplasm and
the nucleus is the classical nuclear import pathway. In this pathway, a protein containing a …

The “classical” nuclear protein import pathway depends on importin α and importin β.
Importin α binds nuclear localization signal (NLS)-bearing proteins and functions as an …

In recent years, our understanding of macromolecular transport processes across the
nuclear envelope has grown dramatically, and a large number of soluble transport receptors …

Nuclear import of proteins containing a classical nuclear localization signal (NLS) involves
NLS recognition by importin α, which associates with importin β via the IBB domain. Other …

The past two years have seen a significant increase in our understanding of nuclear protein
import. Five cytosolic import factors have been identified, two of which have been shown to …

Every minute, several million protein and RNA molecules must be transported between the
cytoplasm and the nucleus of a eukaryotic cell. The characterization of mediators, receptors …