Paradigms in chronic obstructive pulmonary disease: phenotypes, immunobiology, and therapy with a focus on vascular disease

M Schivo, TE Albertson, A Haczku… - Journal of …, 2017 - journals.sagepub.com
Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous syndrome
that represents a major global health burden. COPD phenotypes have recently emerged …

Leveraging Omics to Predict Chronic Obstructive Pulmonary Disease Exacerbations: The “Immunome”

F Polverino, R Kalhan - American journal of respiratory and critical …, 2023 - atsjournals.org
The face of COPD is rapidly evolving. Rather than a superficial view of a self-inflicted
disease of elderly smokers, COPD has now been recognized as a complex condition with …

Correlation of severity of chronic obstructive pulmonary disease with potential biomarkers

S Singh, SK Verma, S Kumar, MK Ahmad, A Nischal… - Immunology letters, 2018 - Elsevier
Background Chronic obstructive pulmonary disease (COPD) is a non-specific inflammation,
which involves the airways, lung parenchyma and pulmonary vessels. The inflammation …

The Challenges of Chronic Obstructive Pulmonary Diseases (COPD)—A Perspective

RW Vandivier, NF Voelkel - COPD: Journal of Chronic Obstructive …, 2005 - Taylor & Francis
Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory disease, primarily
caused by cigarette smoke, which will soon become the third leading cause of death …

Personalizing and targeting therapy for COPD–the role of molecular and clinical biomarkers

F Goh, JG Shaw, SM Savarimuthu Francis… - Expert Review of …, 2013 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized
by persistent airflow limitation. It is the third leading cause of death worldwide, and there are …

Chronic obstructive pulmonary disease and cardiovascular disease

SP Bhatt, MT Dransfield - Translational Research, 2013 - Elsevier
Chronic obstructive pulmonary disease (COPD) is an inflammatory disease of the lung
associated with progressive airflow limitation and punctuated by episodes of acute …

Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype

A Agustí, LD Edwards, SI Rennard, W MacNee… - PloS one, 2012 - journals.plos.org
Background Because chronic obstructive pulmonary disease (COPD) is a heterogeneous
condition, the identification of specific clinical phenotypes is key to developing more effective …

Advances in understanding of mechanisms related to increased cardiovascular risk in COPD

P Rogliani, BL Ritondo, R Laitano… - Expert Review of …, 2021 - Taylor & Francis
Introduction Chronic obstructive pulmonary disease (COPD) represents a serious global
health issue that is commonly associated with cardiovascular (CV) disease (CVD). The close …

Comorbid conditions in chronic obstructive pulmonary disease: Potential therapeutic targets for unmet needs

K Matsunaga, M Harada, J Suizu, K Oishi… - Journal of clinical …, 2020 - mdpi.com
The management of chronic obstructive pulmonary disease (COPD) has improved
significantly due to advances in therapeutic agents, but it has also become apparent that …

COPD: from obstructive lung disease to chronic systemic inflammatory syndrome?

E Wouters - Pneumologie (Stuttgart, Germany), 2009 - europepmc.org
COPD is a complex and heterogeneous disease, in which multiple genes and
environmental factors are involved. The disease is associated with a high risk of comorbidity …