Vascular diseases are major causes of death, yet our understanding of the cellular
constituents of blood vessels, including how differences in their gene expression profiles …

Background: Endothelial cells (ECs) display considerable functional heterogeneity
depending on the vessel and tissue in which they are located. Whereas these functional …

Cerebrovascular disease is the third most common cause of death in developed countries,
but our understanding of the cells that compose the cerebral vasculature is limited. Here …

Objective: Although cellular heterogeneity within arterial walls has been explored in mice
and nonhuman primates, the cellular composition of human arterial walls remains unclear …

Background: Cellular diversity of the lung endothelium has not been systematically
characterized in humans. We provide a reference atlas of human lung endothelial cells …

The ability to quantify DNA, RNA, and protein variations at the single cell level has
revolutionized our understanding of cellular heterogeneity within tissues. Via such analyses …

The heterogeneity of endothelial cells (ECs) across tissues remains incompletely
inventoried. We constructed an atlas of> 32,000 single-EC transcriptomes from 11 mouse …

Cardiovascular disease encompasses a wide range of conditions, resulting in the highest
number of deaths worldwide. The underlying pathologies surrounding cardiovascular …

Vascular endothelial cell (EC) function depends on appropriate organ-specific molecular
and cellular specializations. To explore genomic mechanisms that control this specialization …

Disturbed blood flow (d-flow) has been known to induce changes of the cells in the arterial
wall, increasing the risk of atherosclerosis. However, the heterogeneity of the vascular cell …