[HTML][HTML] Single cell analysis of endothelial cells identified organ-specific molecular signatures and heart-specific cell populations and molecular features
Endothelial cells line the inner surface of vasculature and play an important role in normal
physiology and disease progression. Although most tissue is known to have a …
physiology and disease progression. Although most tissue is known to have a …
Single cell RNA sequencing in atherosclerosis research
Technological advances in characterizing molecular heterogeneity at the single cell level
have ushered in a deeper understanding of the biological diversity of cells present in tissues …
have ushered in a deeper understanding of the biological diversity of cells present in tissues …
[HTML][HTML] Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals
Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective
circulation to compromised tissues in patients. Deciphering the origin and specification of …
circulation to compromised tissues in patients. Deciphering the origin and specification of …
[HTML][HTML] The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells
The blood-brain barrier (BBB) maintains brain homeostasis and limits the entry of toxins and
pathogens into the brain. Despite its importance, little is known about the molecular …
pathogens into the brain. Despite its importance, little is known about the molecular …
[HTML][HTML] SINCERA: a pipeline for single-cell RNA-Seq profiling analysis
A major challenge in developmental biology is to understand the genetic and cellular
processes/programs driving organ formation and differentiation of the diverse cell types that …
processes/programs driving organ formation and differentiation of the diverse cell types that …
[HTML][HTML] The expanding cell diversity of the brain vasculature
The cerebrovasculature is essential to brain health and is tasked with ensuring adequate
delivery of oxygen and metabolic precursors to ensure normal neurologic function. This is …
delivery of oxygen and metabolic precursors to ensure normal neurologic function. This is …
[HTML][HTML] Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation
Blood vessels are lined by endothelial cells engaged in distinct organ-specific functions but
little is known about their characteristic gene expression profiles. RNA-Sequencing of the …
little is known about their characteristic gene expression profiles. RNA-Sequencing of the …
Microanatomy of the human atherosclerotic plaque by single-cell transcriptomics
MAC Depuydt, KHM Prange, L Slenders, T Örd… - Circulation …, 2020 - Am Heart Assoc
Rationale: Atherosclerotic lesions are known for their cellular heterogeneity, yet the
molecular complexity within the cells of human plaques has not been fully assessed …
molecular complexity within the cells of human plaques has not been fully assessed …
[PDF][PDF] Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis
L Slenders, LPL Landsmeer, K Cui… - … heart journal open, 2022 - academic.oup.com
Aims Genome-wide association studies (GWASs) have discovered hundreds of common
genetic variants for atherosclerotic disease and cardiovascular risk factors. The translation of …
genetic variants for atherosclerotic disease and cardiovascular risk factors. The translation of …
[HTML][HTML] Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs
Background As core units of organ tissues, cells of various types play their harmonious
rhythms to maintain the homeostasis of the human body. It is essential to identify the …
rhythms to maintain the homeostasis of the human body. It is essential to identify the …