[PDF][PDF] In silico identification of novel drug targets in acinetobacter baumannii by subtractive genomic approach

M Goyal, C Citu, N Singh - Asian J. Pharm. Clin. Res, 2018 - researchgate.net
Objective: Multiple drug resistance (MDR) in bacteria, particularly Gram-negative bacilli, has
significantly hindered the treatment of infections caused by these bacteria. This results in the …

Identification of putative non-host essential genes and novel drug targets against Acinetobacter baumannii by in silico comparative genome analysis

R Uddin, F Masood, SS Azam, A Wadood - Microbial pathogenesis, 2019 - Elsevier
Acinetobacter baumannii, the gram-negative bacteria emerged as an extremely critical
pathogen causing nosocomial and different kinds of infections. A. baumannii exhibit …

Identification of novel non-homologous drug targets against Acinetobacter baumannii using subtractive genomics and comparative metabolic pathway analysis

H Kaur, M Kalia, N Taneja - Microbial Pathogenesis, 2021 - Elsevier
Lack of effective antibiotics and the development of multidrug resistance in clinical isolates
of nosocomial pathogen Acinetobacter baumanni has necessitated the identification of novel …

In Silico Identification of Probable Drug and Vaccine Candidates Against Antibiotic-Resistant Acinetobacter baumannii

E Zadeh Hosseingholi, G Zarrini… - Microbial Drug …, 2020 - liebertpub.com
Acinetobacter baumannii is known as a Gram-negative bacterium that has become one of
the most important health problems due to antibiotic resistance. Today, numerous efforts are …

Computer-Based Identification of Potential Druggable Targets in Multidrug-Resistant Acinetobacter baumannii: A Combined In Silico, In Vitro and In Vivo Study

OH Badie, AF Basyony, R Samir - Microorganisms, 2022 - mdpi.com
The remarkable rise in antimicrobial resistance is alarming for Acinetobacter baumannii,
which necessitates effective strategies for the discovery of promising anti-acinetobacter …

Genome-Wide Identification of Potential Drug Target in Enterobacteriaceae Family: A Homology-Based Method

M Hadizadeh, SN Tabatabaiepour… - Microbial Drug …, 2018 - liebertpub.com
The Enterobacteriaceae is a large family of Gram-negative, facultative anaerobic, non-spore
forming rod-shaped bacteria that includes harmless and pathogenic organisms. The …

Identification and characterization of potential drug targets by subtractive genome analyses of methicillin resistant Staphylococcus aureus

R Uddin, K Saeed - Computational biology and chemistry, 2014 - Elsevier
Methicillin resistant Staphylococcus aureus (MRSA) causes serious infections in humans
and becomes resistant to a number of antibiotics. Due to the emergence of antibiotic …

Identification of Druggable Targets for Acinetobacter baumannii Via Subtractive Genomics and Plausible Inhibitors for MurA and MurB

N Kaur, M Khokhar, V Jain, PV Bharatam… - Applied biochemistry …, 2013 - Springer
Emergence of the multidrug-resistant pathogens has rendered the current therapies
ineffective thereby, resulting in the need for new drugs and drug targets. The accumulating …

In silico identification of putative drug targets from different metabolic pathways of Aeromonas hydrophila

V Sharma, P Gupta, A Dixit - In silico biology, 2008 - content.iospress.com
Aeromonas hydrophila is a major pathogen both of aquatic and terrestrial organisms,
including humans. Infection with A. hydrophila results in severe economic losses to the …

In Silico Identification and Characterization of Drug Targets in Streptococcus pneumoniae ATCC 700669 (Serotype 23F) by Subtractive Genomics

T Duguma, H Dinka - BioMed Research International, 2024 - Wiley Online Library
Streptococcus pneumoniae (S. pneumoniae) is an important pathogen worldwide that
causes pneumococcal infections which are related to high rates of morbidity and mortality …