Comparing novel antibiotics and carbapenems for complicated intra-abdominal infections: a systematic review and meta-analysis of randomized controlled trials

TYT Chen, CK Hsu, SC Shih, TS Weng, HJ Tang… - International Journal of …, 2023 - Elsevier
Background Carbapenem-sparing antibiotics are needed urgently for patients with
complicated intra-abdominal infections (cIAIs). Although several novel antibiotics–novel β …

Carbapenems vs β-lactam monotherapy or combination therapy for the treatment of complicated intra-abdominal infections: systematic review and meta-analysis of …

Y Li, L Chen, J Jiang, X Li, T Huang… - Open Forum Infectious …, 2019 - academic.oup.com
Background Complicated intra-abdominal infections (cIAIs) result in significant morbidity,
mortality, and cost. Carbapenem-resistant sepsis has increased dramatically in the last …

Novel Beta-Lactam/Beta-Lactamase plus metronidazole vs carbapenem for complicated intra-abdominal infections: a Meta-analysis of randomized controlled trials

H Che, J Wang, R Wang, Y Cai - Open Forum Infectious …, 2021 - academic.oup.com
Background Complicated intra-abdominal infections (cIAIs) remain a leading cause of death
in surgical wards, in which antibiotic treatment is crucial. We aimed to compare the efficacy …

Efficacy, safety, and tolerability of antimicrobial agents for complicated intra-abdominal infection: a systematic review and network meta-analysis

W Kong, T Deng, S Li, Y Shu, Y Wu - BMC Infectious Diseases, 2023 - Springer
Background Which antimicrobial agents provide the optimal efficacy, safety, and tolerability
for the empirical treatment of complicated intra-abdominal infection (cIAI) remains unclear …

New antimicrobial options for the management of complicated intra-abdominal infections

S Leone, G Damiani, I Pezone, ME Kelly… - European Journal of …, 2019 - Springer
Complicated intra-abdominal infections (cIAIs) are a common cause of morbidity and
mortality in surgical patients. Optimal management of cIAI requires early source control in …

Carbapenem antibiotics versus other antibiotics for complicated intra-abdominal infections: a systematic review and patient-level meta-analysis of randomized …

A Rebelo, L Schlicht, J Kleeff, CW Michalski… - Journal of …, 2023 - Elsevier
Background The treatment of complicated intra-abdominal infections remains a challenge.
Both optimal medical and surgical therapy (ie, source control) are needed to achieve low …

Complicated intra-abdominal infections: the old antimicrobials and the new players

YR Lee, D McMahan, C McCall, GK Perry - Drugs, 2015 - Springer
Complicated intra-abdominal infections (cIAIs) are an important cause of morbidity and
mortality worldwide. They are diagnosed when the initial abdominal organ infection has …

Carbapenems vs tigecycline for the treatment of complicated intra-abdominal infections: a Bayesian network meta-analysis of randomized clinical trials

L Chen, X Liang, J Jiang, X Li, Y Li - Medicine, 2019 - journals.lww.com
Background: Complicated intra-abdominal infections (cIAIs) are common in clinical practice,
caused by a mixture of aerobic and anaerobic bacteria, increase the risk of mortality …

New and emerging antibiotics for complicated intra-abdominal infections

CR Durand, M Alsharhan, KC Willett - American Journal of …, 2017 - journals.lww.com
The purpose of this review is to evaluate the efficacy and safety of ceftazidime/avibactam
and ceftolozane/tazobactam in patients with complicated intra-abdominal infections (cIAI) …

Ceftazidime–Avibactam versus Meropenem for the Treatment of Complicated Intra-Abdominal Infections

CK Tan, CC Lai, CM Chao - Antibiotics, 2019 - mdpi.com
This study reports an integrated analysis of three randomized controlled trials to compare
the clinical efficacies and safety of the ceftazidime–avibactam (CAZ–AVI) combination and …