Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice

X Bian, W Wu, L Yang, L Lv, Q Wang, Y Li… - Frontiers in …, 2019 - frontiersin.org
Inflammatory bowel diseases (IBDs) develop as a result of complex interactions among
genes, innate immunity and environmental factors, which are related to the gut microbiota …

Akkermansia muciniphila Exerts Strain-Specific Effects on DSS-Induced Ulcerative Colitis in Mice

Q Liu, W Lu, F Tian, J Zhao, H Zhang… - Frontiers in cellular and …, 2021 - frontiersin.org
Akkermansia muciniphila is a commensal bacterium of the gut mucus layer. Although both in
vitro and in vivo data have shown that A. muciniphila strains exhibit strain-specific …

A β-N-acetylhexosaminidase Amuc_2109 from Akkermansia muciniphila protects against dextran sulfate sodium-induced colitis in mice by enhancing intestinal barrier …

K Qian, S Chen, J Wang, K Sheng, Y Wang… - Food & Function, 2022 - pubs.rsc.org
Inflammatory bowel disease (IBD) is associated with the microbial composition of the gut
and its metabolites. Akkermansia muciniphila is a probiotic that exerts a significant …

Akkermansia muciniphila alleviates dextran sulfate sodium (DSS)-induced acute colitis by NLRP3 activation

S Qu, L Fan, Y Qi, C Xu, Y Hu, S Chen, W Liu… - Microbiology …, 2021 - Am Soc Microbiol
Akkermansia muciniphila has been proved to play a crucial role in the progression of colitis,
but its underlying mechanism remains inconclusive. In this study, we aim to investigate the …

The effects of live and pasteurized Akkermansia muciniphila on DSS-induced ulcerative colitis, gut microbiota, and metabolomics in mice

L Xue, Y Zhao, H Wang, Z Li, T Wu, R Liu, W Sui… - Food & Function, 2023 - pubs.rsc.org
Akkermansia muciniphila (A. muciniphila) plays an important role in intestinal regulation,
while it is presently unclear whether live or pasteurized A. muciniphila has different effects …

Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice

R Zhai, X Xue, L Zhang, X Yang, L Zhao… - Frontiers in cellular and …, 2019 - frontiersin.org
Akkermansia muciniphila is potential probiotic in that its type strain ATCC BAA-835 has
beneficial effects upon obesity and diabetes. However, whether A. muciniphila can improve …

Metformin exerts anti-inflammatory and mucus barrier protective effects by enriching Akkermansia muciniphila in mice with ulcerative colitis

H Ke, F Li, W Deng, Z Li, S Wang, P Lv… - Frontiers in …, 2021 - frontiersin.org
The present study aimed to determine if metformin exerts anti-inflammatory and mucus-
protective effects via the gut microbiota. Metformin has extensive benefits including anti …

Stable colonization of Akkermansia muciniphila educates host intestinal microecology and immunity to battle against inflammatory intestinal diseases

B Wang, X Chen, Z Chen, H Xiao, J Dong, Y Li… - … & Molecular Medicine, 2023 - nature.com
Gut microbial preparations are widely used in treating intestinal diseases but show mixed
success. In this study, we found that the therapeutic efficacy of A. muciniphila for dextran …

Akkermansia muciniphila and Gut Immune System: A Good Friendship That Attenuates Inflammatory Bowel Disease, Obesity, and Diabetes

VF Rodrigues, J Elias-Oliveira, ÍS Pereira… - Frontiers in …, 2022 - frontiersin.org
Akkermansia muciniphila is a Gram-negative anaerobic mucus-layer-degrading bacterium
that colonizes the intestinal mucosa of humans and rodents. Metagenomic data have shown …

[HTML][HTML] Akkermansia muciniphila administration exacerbated the development of colitis-associated colorectal cancer in mice

F Wang, K Cai, Q Xiao, L He, L Xie, Z Liu - Journal of Cancer, 2022 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the most common digestive tract malignancies and
inflammation and gut microbiota are well-known key factors to influence CRC development …