Structure of a pathogenic type 3 secretion system in action

J Radics, L Königsmaier, TC Marlovits - Nature structural & molecular …, 2014 - nature.com
Abstract Type 3 secretion systems use 3.5-megadalton syringe-like, membrane-embedded'
injectisomes', each containing an~ 800-Å-long needle complex to connect intracellular …

[HTML][HTML] Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation

S Miletic, D Fahrenkamp, N Goessweiner-Mohr… - Nature …, 2021 - nature.com
Many bacterial pathogens rely on virulent type III secretion systems (T3SSs) or injectisomes
to translocate effector proteins in order to establish infection. The central component of the …

High-resolution view of the type III secretion export apparatus in situ reveals membrane remodeling and a secretion pathway

C Butan, M Lara-Tejero, W Li, J Liu… - Proceedings of the …, 2019 - National Acad Sciences
Type III protein secretion systems are essential virulence factors for many important
pathogenic bacteria. The entire protein secretion machine is composed of several …

[HTML][HTML] Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin

J Hu, LJ Worrall, C Hong, M Vuckovic… - Nature …, 2018 - nature.com
The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine
essential for the virulence of many disease causing Gram-negative bacteria. At the core of …

T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly

J Hu, LJ Worrall, M Vuckovic, C Hong, W Deng… - Nature …, 2019 - nature.com
The bacterial injectisome is a syringe-shaped macromolecular nanomachine utilized by
many pathogenic Gram-negative bacteria, including the causative agents of plague, typhoid …

Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body

LJ Worrall, C Hong, M Vuckovic, W Deng… - Nature, 2016 - nature.com
The type III secretion (T3S) injectisome is a specialized protein nanomachine that is critical
for the pathogenicity of many Gram-negative bacteria, including purveyors of plague, typhoid …

Piecing together the type III injectisome of bacterial pathogens

TF Moraes, T Spreter, NCJ Strynadka - Current opinion in structural biology, 2008 - Elsevier
The Type III secretion system is a bacterial 'injectisome'which allows Gram-negative bacteria
to shuttle virulence proteins directly into the host cells they infect. This macromolecular …

[HTML][HTML] In situ molecular architecture of the Salmonella type III secretion machine

B Hu, M Lara-Tejero, Q Kong, JE Galán, J Liu - Cell, 2017 - cell.com
Type III protein secretion systems have specifically evolved to deliver bacterially encoded
proteins into target eukaryotic cells. The core elements of this multi-protein machine are the …

Bacterial type III secretion systems: a complex device for the delivery of bacterial effector proteins into eukaryotic host cells

S Wagner, I Grin, S Malmsheimer… - FEMS microbiology …, 2018 - academic.oup.com
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial
effector proteins into eukaryotic host cells. They are able to secrete a great diversity of …

[HTML][HTML] A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly

JRC Bergeron, LJ Worrall, NG Sgourakis… - PLoS …, 2013 - journals.plos.org
The T3SS injectisome is a syringe-shaped macromolecular assembly found in pathogenic
Gram-negative bacteria that allows for the direct delivery of virulence effectors into host cells …