Structure of a pathogenic type 3 secretion system in action
J Radics, L Königsmaier, TC Marlovits - Nature structural & molecular …, 2014 - nature.com
Abstract Type 3 secretion systems use 3.5-megadalton syringe-like, membrane-embedded'
injectisomes', each containing an~ 800-Å-long needle complex to connect intracellular …
injectisomes', each containing an~ 800-Å-long needle complex to connect intracellular …
[HTML][HTML] Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation
S Miletic, D Fahrenkamp, N Goessweiner-Mohr… - Nature …, 2021 - nature.com
Many bacterial pathogens rely on virulent type III secretion systems (T3SSs) or injectisomes
to translocate effector proteins in order to establish infection. The central component of the …
to translocate effector proteins in order to establish infection. The central component of the …
High-resolution view of the type III secretion export apparatus in situ reveals membrane remodeling and a secretion pathway
C Butan, M Lara-Tejero, W Li, J Liu… - Proceedings of the …, 2019 - National Acad Sciences
Type III protein secretion systems are essential virulence factors for many important
pathogenic bacteria. The entire protein secretion machine is composed of several …
pathogenic bacteria. The entire protein secretion machine is composed of several …
[HTML][HTML] Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin
The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine
essential for the virulence of many disease causing Gram-negative bacteria. At the core of …
essential for the virulence of many disease causing Gram-negative bacteria. At the core of …
T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly
The bacterial injectisome is a syringe-shaped macromolecular nanomachine utilized by
many pathogenic Gram-negative bacteria, including the causative agents of plague, typhoid …
many pathogenic Gram-negative bacteria, including the causative agents of plague, typhoid …
Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body
The type III secretion (T3S) injectisome is a specialized protein nanomachine that is critical
for the pathogenicity of many Gram-negative bacteria, including purveyors of plague, typhoid …
for the pathogenicity of many Gram-negative bacteria, including purveyors of plague, typhoid …
Piecing together the type III injectisome of bacterial pathogens
TF Moraes, T Spreter, NCJ Strynadka - Current opinion in structural biology, 2008 - Elsevier
The Type III secretion system is a bacterial 'injectisome'which allows Gram-negative bacteria
to shuttle virulence proteins directly into the host cells they infect. This macromolecular …
to shuttle virulence proteins directly into the host cells they infect. This macromolecular …
[HTML][HTML] In situ molecular architecture of the Salmonella type III secretion machine
Type III protein secretion systems have specifically evolved to deliver bacterially encoded
proteins into target eukaryotic cells. The core elements of this multi-protein machine are the …
proteins into target eukaryotic cells. The core elements of this multi-protein machine are the …
Bacterial type III secretion systems: a complex device for the delivery of bacterial effector proteins into eukaryotic host cells
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial
effector proteins into eukaryotic host cells. They are able to secrete a great diversity of …
effector proteins into eukaryotic host cells. They are able to secrete a great diversity of …
[HTML][HTML] A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly
The T3SS injectisome is a syringe-shaped macromolecular assembly found in pathogenic
Gram-negative bacteria that allows for the direct delivery of virulence effectors into host cells …
Gram-negative bacteria that allows for the direct delivery of virulence effectors into host cells …