Toll-like receptor signaling and subsequent activation of NF-κB–and MAPK-dependent
genes during infection play an important role in antimicrobial host defense. The YopJ protein …

Caspases regulate cell death programs in response to environmental stresses, including
infection and inflammation, and are therefore critical for the proper operation of the …

Many pathogens deliver virulence factors or effectors into host cells in order to evade host
defenses and establish infection. Although such effector proteins disrupt critical cellular …

A number of pathogens cause host cell death upon infection, and Yersinia pestis, infamous
for its role in large pandemics such as the “Black Death” in medieval Europe, induces …

Bacterial pathogens from the genus Yersinia cause fatal sepsis and gastritis in humans.
Innate immune signaling and inflammatory cell death (pyroptosis, apoptosis, and …

Macrophages respond to infection with pathogenic Yersinia species by activating MAPK-and
NF-κB-signaling pathways. To counteract this response, Yersiniae secrete a protease …

Macrophages encode several Toll-like receptors (TLRs) that recognize bacterial
components, such as lipoproteins (TLR2) or lipopolysaccharides (TLR4), and activate …

The bacterial pathogens of the genus Yersinia, the causative agents of plague, septicemia,
and gastrointestinal syndromes, use a type III secretion system to inject virulence factors into …

Upon exposure to bacteria, eukaryotic cells activate signalling pathways that result in the
increased expression of several defence‐related genes. Here, we report that the yopJ locus …

The induction of apoptosis in host cells is a common strategy by which pathogenic bacteria
interfere with the host immune response. The Yersinia enterocolitica outer protein P (YopP) …