The field of asthma genetics has progressed rapidly over the past decade, implicating many
genes and variants in the etiology of this complex disease. However, many of these factors …

Asthma is a common complex disease of the airways. Genome-wide association studies
(GWASs) of asthma have identified many risk alleles and loci that have been replicated in …

Genome-wide association studies (GWAS) of asthma have yielded exciting results and
identified novel risk alleles and loci. But, like other common complex diseases, asthma …

Moving beyond traditional GWAS formats is likely to significantly enhance our understanding
of the genetic basis for asthma. This review discusses where we are after half a decade of …

The next wave of asthma genetic studies will use full-genome sequencing and overcome
most GWAS-associated problems. It will be the last step of a century-long search for asthma …

In the era of genome-wide association (GWA) studies, delineating pathogenic asthma
genetic pathways has provided both challenges and opportunities. Initial GWA studies on …

Understanding disease pathogenesis is essential to improve diagnostic methods, increase
prognostic accuracy, and identify therapeutic targets. Human genetics can play a unique …

Background Hundreds of genetic variants are thought to contribute to variation in asthma
risk by modulating gene expression. Methods that increase the power of genome-wide …

Bronchial asthma is a common inflammatory disease caused by a combination of genetic
and environmental factors. To discover the genes and cellular pathways underlying asthma …

Asthma is a complex syndrome leading to the easily recognizable clinical feature of
wheezing. This is believed to be caused by inflammation, constriction of the airway smooth …