Systems biology of cancer: a challenging expedition for clinical and quantitative biologists
I Korsunsky, K McGovern, T LaGatta… - … in Bioengineering and …, 2014 - frontiersin.org
A systems-biology approach to complex disease (such as cancer) is now complementing
traditional experience-based approaches, which have typically been invasive and …
traditional experience-based approaches, which have typically been invasive and …
Computational systems biology in cancer: modeling methods and applications
W Materi, DS Wishart - Gene regulation and systems biology, 2007 - journals.sagepub.com
In recent years it has become clear that carcinogenesis is a complex process, both at the
molecular and cellular levels. Understanding the origins, growth and spread of cancer …
molecular and cellular levels. Understanding the origins, growth and spread of cancer …
Systems biology for cancer
IG Khalil, C Hill - Current opinion in oncology, 2005 - journals.lww.com
An important challenge facing the field is how better to translate in vitro discoveries to the
clinic. Computational systems biology approaches that use omic data to predict biology …
clinic. Computational systems biology approaches that use omic data to predict biology …
[图书][B] Cancer systems biology
E Wang - 2010 - books.google.com
The unprecedented amount of data produced with high-throughput experimentation forces
biologists to employ mathematical representation and computation to glean meaningful …
biologists to employ mathematical representation and computation to glean meaningful …
Computational tools and resources for systems biology approaches in cancer
A Daskalaki, C Wierling, R Herwig - Computational Biology: Issues and …, 2009 - Springer
Abstract Systems biology focuses on the study of interacting components of biological
systems rather than on the analysis of single genes or proteins and offers a new approach to …
systems rather than on the analysis of single genes or proteins and offers a new approach to …
Constructing predictive cancer systems biology models
JA Rohrs, SZ Makaryan, SD Finley - bioRxiv, 2018 - biorxiv.org
Abstract Systems biology combines computational modeling with quantitative experimental
measurements to study complex biological processes. Here, we outline an approach for …
measurements to study complex biological processes. Here, we outline an approach for …
Systems biology and cancer: promises and perils
SG Baker, BS Kramer - Progress in biophysics and molecular biology, 2011 - Elsevier
Systems biology uses systems of mathematical rules and formulas to study complex
biological phenomena. In cancer research there are three distinct threads in systems biology …
biological phenomena. In cancer research there are three distinct threads in systems biology …
Cancer systems biology
D Faratian, JL Bown, VA Smith, SP Langdon… - Systems Biology in Drug …, 2010 - Springer
Cancer is a complex and heterogeneous disease, not only at a genetic and biochemical
level, but also at a tissue, organism, and population level. Multiple data streams, from …
level, but also at a tissue, organism, and population level. Multiple data streams, from …
In silico models of cancer
Cancer is a complex disease that involves multiple types of biological interactions across
diverse physical, temporal, and biological scales. This complexity presents substantial …
diverse physical, temporal, and biological scales. This complexity presents substantial …
A systems biology view of cancer
In order to understand how a cancer cell is functionally different from a normal cell it is
necessary to assess the complex network of pathways involving gene regulation, signaling …
necessary to assess the complex network of pathways involving gene regulation, signaling …