Recent evidence has implicated collagen, particularly fibrillar collagen, in a number of
diseases ranging from osteogenesis imperfecta and asthma to breast and ovarian cancer. A …

In this work, we outline an automated method for the extraction and quantification of material
parameters characterizing collagen fibre orientations from two-dimensional images …

Quantification of fibrillar collagen organization has given new insight into the possible role of
collagen topology in many diseases and has also identified candidate image-based bio …

The mechanical behavior of soft connective tissue is governed by a dense network of fibrillar
proteins in the extracellular matrix. Characterization of this fibrous network requires the …

Stromal collagen alignment has been shown to have clinical significance in a variety of
cancers and in other diseases accompanied by fibrosis. While much of the biological and …

The importance of fibrillar collagen topology and organization in disease progression and
prognostication in different types of cancer has been characterized extensively in many …

Collagen is the most prominent protein of human tissues. Its content and organization define
to a large extent the mechanical properties of tissue as well as its function. Methods that …

Cells cultured in 3D fibrous biopolymer matrices exert traction forces on their environment
that induce deformations and remodeling of the fiber network. By measuring these …

Quantitative second-harmonic generation imaging is employed to assess stromal collagen
in normal, hyperplastic, dysplastic, and malignant breast tissues. The cellular scale …

A number of histopathology studies have utilized the label free microscopy method of
Second Harmonic Generation (SHG) to investigate collagen organization in disease onset …