Ganoderma lucidum polysaccharide (GLP) enhances antitumor immune response by regulating differentiation and inhibition of MDSCs via a CARD9-NF-κB-IDO …

Y Wang, X Fan, X Wu - Bioscience Reports, 2020 - portlandpress.com
A homogeneous polysaccharide (GLP), with an average molecular weight of 4.44× 104 Da,
was isolated and purified from the fruiting bodies of Ganoderma lucidum. In this work, we …

Immunomodulatory effect of Ganoderma atrum polysaccharide on CT26 tumor-bearing mice

S Zhang, S Nie, D Huang, W Li, M Xie - Food Chemistry, 2013 - Elsevier
Ganoderma atrum has attracted great attention for its antitumor activity. However, the
mechanism remains unclear. A G. atrum polysaccharide (PSG-1) showed pronounced …

Polysaccharide from Ganoderma atrum evokes antitumor activity via Toll-like receptor 4-mediated NF-κB and mitogen-activated protein kinase signaling pathways

S Zhang, S Nie, D Huang, J Huang… - Journal of agricultural …, 2013 - ACS Publications
Ganoderma atrum has been used as a traditional Chinese medicine for centuries. In this
study, the antitumor activity of a novel G. atrum polysaccharide (PSG-1) was investigated in …

Promoting Effects of Ganoderma lucidum Polysaccharides on B16F10 Cells to Activate Lymphocytes

LX Sun, ZB Lin, XJ Li, M Li, J Lu… - Basic & Clinical …, 2011 - Wiley Online Library
The immune system in patients with cancer often fails to control tumour growth because of
deficient immunogenicity of tumour cells. Ganoderma lucidum polysaccharides (Gl‐PS) are …

GLIS, a bioactive proteoglycan fraction from Ganoderma lucidum, displays anti-tumour activity by increasing both humoral and cellular immune response

J Zhang, Q Tang, C Zhou, W Jia, L Da Silva… - Life sciences, 2010 - Elsevier
AIMS: Ganoderma lucidum, a traditional Chinese medicine, is well known as a modulator of
functions of the immune system as well as an anti-tumour agent. However, its active …

Antitumor and Immunomodulatory Activities of Ganoderma lucidum Polysaccharides in Glioma-Bearing Rats

C Wang, S Shi, Q Chen, S Lin, R Wang… - Integrative cancer …, 2018 - journals.sagepub.com
Malignant gliomas are the most common brain tumors with high rates of recurrence and
mortality. Novel approaches are in research, and immunotherapy emerges as a promising …

Antitumor Activity and Underlying Mechanisms of Ganopoly, The Refined Polysaccharides Extracted from Ganoderma Lucidum, in Mice

Y Gao, H Gao, E Chan, W Tang, A Xu… - Immunological …, 2005 - Taylor & Francis
Ganopoly is an aqueous polysaccharide fraction extracted from G. lucidum by patented
biochemical technique and has been marketed as an over-the-counter product for chronic …

Immune receptors for polysaccharides from Ganoderma lucidum

BM Shao, H Dai, W Xu, ZB Lin, XM Gao - Biochemical and Biophysical …, 2004 - Elsevier
This study was designed to identify and characterize the immune receptors for
polysaccharides from Ganoderma lucidum, a Chinese medicinal fungus that exhibits anti …

Chemical Characterization and Antitumor Activities of Polysaccharide Extracted from Ganoderma lucidum

Z Liang, Y Yi, Y Guo, R Wang, Q Hu… - International journal of …, 2014 - mdpi.com
Ganoderma lucidum polysaccharide (GLP) is a biologically active substance reported to
possess anti-tumor ability. Nonetheless, the mechanisms of GLP-stimulated apoptosis are …

Ganoderma atrum polysaccharide modulates TNF-α secretion and mRNA expression in macrophages of S-180 tumor-bearing mice

J Huang, Q Nie, X Liu, S Zhang, S Nie, D Huang… - Food …, 2016 - Elsevier
Previous researches focused on the chemical structure of Ganoderma atrum polysaccharide
(PSG-1), and found it has antitumor and immunoregulatory activities. However, the …