The IL-1 Receptor Is Required to Maintain Neutrophil Viability and Function During Aspergillus fumigatus Airway Infection

BAWR Ralph, M Lehoux, H Ostapska… - Frontiers in …, 2021 - frontiersin.org
Aspergillus fumigatus airway infections are associated with increased rates of
hospitalizations and declining lung function in patients with chronic lung disease. While the …

The clinical spectrum of pulmonary aspergillosis

AO Soubani, PH Chandrasekar - Chest, 2002 - Elsevier
Aspergillus is a ubiquitous fungus that causes a variety of clinical syndromes in the lung,
ranging from aspergilloma in patients with lung cavities, to chronic necrotizing aspergillosis …

Minireview: host defence in invasive aspergillosis

C Lass‐Flörl, E Roilides, J Löffler, D Wilflingseder… - Mycoses, 2013 - Wiley Online Library
Aspergillus is a saprophytic fungus, which mainly becomes pathogenic in
immunosuppressed hosts. A failure of host defences results in a diverse set of illnesses …

Aspergillus fumigatus conidia induce interferon-β signalling in respiratory epithelial cells

C Beisswenger, C Hess, R Bals - European Respiratory Journal, 2012 - Eur Respiratory Soc
Aspergillus fumigatus is a fungal pathogen of major clinical importance. However, little is
known about the role of human bronchial epithelial cells (HBECs) during A. fumigatus …

Hypoxia attenuates anti‐Aspergillus fumigatus immune responses initiated by human dendritic cells

M Fliesser, M Wallstein, O Kurzai, H Einsele… - Mycoses, 2016 - Wiley Online Library
Aspergillus fumigatus is an opportunistic mould that causes invasive pulmonary
aspergillosis (IPA), a life‐threatening infection in immunocompromised patients. During the …

Aspergillosis and stem cell transplantation: An overview of experimental pathogenesis studies

N Al-Bader, DC Sheppard - Virulence, 2016 - Taylor & Francis
Invasive aspergillosis is a life-threatening infection caused by the opportunistic filamentous
fungus Aspergillus fumigatus. Patients undergoing haematopoietic stem cell transplant …

Systemic fungal infections caused by Aspergillus species: epidemiology, infection process and virulence determinants

AA Brakhage - Current drug targets, 2005 - ingentaconnect.com
Infections with mould pathogens have emerged as an increasing risk faced by patients
under sustained immunosuppression. Species of the Aspergillus family account for most of …

Invasion of the alveolar-capillary barrier by Aspergillus spp.: therapeutic and diagnostic implications for immunocompromised patients with invasive pulmonary …

WW Hope - Medical Mycology, 2009 - academic.oup.com
Aspergillus spp. are leading causes of morbidity and mortality in immunocompromised
patients. This review provides an overview of host defenses, the mechanisms by which the …

Differential Proinflammatory Responses to Aspergillus fumigatus by Airway Epithelial Cells In Vitro Are Protease Dependent

J Rowley, S Namvar, S Gago, B Labram, P Bowyer… - Journal of Fungi, 2021 - mdpi.com
Aspergillus fumigatus is an important human respiratory mould pathogen. In addition to a
barrier function, airway epithelium elicits a robust defence against inhaled A. fumigatus by …

Enemy of the (immunosuppressed) state: an update on the pathogenesis of Aspergillus fumigatus infection

R Ben‐Ami, RE Lewis… - British journal of …, 2010 - Wiley Online Library
Aspergillus fumigatus is an opportunistic filamentous fungus that is currently the most
frequent cause of invasive fungal disease in immunosuppressed individuals. Recent …