The in-house IIIM natural product repository of 302 small molecules was screened for their
ability to inhibit P-glycoprotein (Pgp) in Pgp-overexpressing human adenocarcinoma LS …

Staphylococcus aureus is a serious causative agent of infectious disease. Multidrug-
resistant strains like methicillin-resistant S. aureus compromise treatment efficacy, causing …

The discovery of antibiotics has significantly transformed the outcomes of bacterial infections
in the last decades. However, the development of antibiotic resistance mechanisms has …

Since the discovery of the first antibiotics, bacteria have acquired a variety of resistance
mechanisms, with efflux pump (EP) being the most prominent mechanism for intracellular …

Introduction: Infectious diseases have been responsible for an increasing number of deaths
worldwide. Staphylococcus aureus has been recognized as one of the most notable …

Bacterial resistance induced by efflux pumps is a frequent concern in clinical treatments
involving multi-resistant bacteria. Staphylococcus aureus is a microorganism responsible for …

Polysubstituted pyrrole natural products, lamellarins, are known to overcome multi-drug
resistance in cancer via the inhibition of p-glycoprotein (P-gp) and breast cancer resistance …

Coumarins are compounds with scientifically proven antibacterial properties, and
modifications to the chemical structure are known to improve their effects. This information is …

Staphylococcus aureus is a serious human pathogen that is highly adaptive to
environmental conditions and rapidly develops antibiotic resistance. The use of efflux pumps …

Objectives Evaluation of novel synthetic analogues of piperine as inhibitors of multidrug
efflux pump NorA of Staphylococcus aureus. Methods A library of piperine-derived …