The action of extracellular nucleotides, specifically the ability of adenine nucleotides to
induce coronary vasodilation and bradycardia, was first described more than 70 years ago …

To isolate the mouse P2Y4 receptor gene, a mouse genomic library was screened with a
human P2Y4 probe. An open reading frame encoding a protein of 361 amino acids was …

A P2Y receptor with 65% identity to mammalian P2Y6receptors, termed the p2y3 receptor,
was recently cloned from a chick brain cDNA library and was proposed to represent a novel …

The P2Y13 receptor has recently been identified as a new P2Y receptor sharing a high
sequence homology with the P2Y12 receptor as well as similar functional properties …

Nucleotides signal through purinergic receptors such as the P2 receptors, which are
subdivided into the ionotropic P2X receptors and the metabotropic P2Y receptors. The …

The release of nucleotides in extracellular fluids can result from cell necrosis, exocytosis of
secretory granules (such as platelet‐dense granules), vesicular trafficking, or efflux through …

A recently cloned G protein-coupled receptor (named the p2y7 receptor) with relatively low
sequence identity to previously cloned P2Y receptors was proposed to be a member of this …

The P2 family of membrane-bound receptors is activated by naturally occurring nucleotides.
When activated, these widely distributed receptors elicit cellular signaling which mediate …

An orphan G protein-coupled receptor, termed 6H1, with∼ 30% sequence identity to P2Y
receptors has been proposed to be a P2Y receptor (p2y5) based solely on a radioligand …

The function of a neuron critically depends on the opening and closure of Ca2+ and K+
channels. Voltage-activated Ca2+ channels mediate transmembrane Ca2+ entry in …